Document Detail

Transient cardiac ballooning--the syndrome.
MedLine Citation:
PMID:  19938049     Owner:  NLM     Status:  MEDLINE    
Transient cardiac ballooning is usually a reversible clinical entity. A patient typically presents with chest pain, electrocardiogram (ECG) abnormalities like ST-segment elevation (most commonly reported) or depression, and elevated cardiac enzymes, but has no or nonobstructive coronary artery disease. Left ventriculography reveals transient akinesis of the involved portion of the myocardial wall with compensatory hyperkinesis of the remaining myocardium, leading to ballooning of the noncontracting myocardial wall during systole. Acute regional myocardial dysfunction ensues, which normalizes on average within 1 to 6 weeks. The hypotheses for these pathophysiologic changes range from direct cardiac myocyte injury to postischemic myocardial stunning to neurotransmitter actions. The objective of this article is to present a succinct description of a small case series accompanied with various recently reported presentations and morphology by left ventriculogram and a detailed review of available data on underlying pathophysiology. In addition, a discussion on current diagnostic guidelines, treatment, prognosis, and potential future investigations is included.
Raghav Gupta; Candice Sech; Ralph Lazzara
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical cardiology     Volume:  32     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-04     Revised Date:  2010-04-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-20     Citation Subset:  IM    
Section of Cardiovascular Diseases, Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
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MeSH Terms
Angina Pectoris / etiology
Biological Markers / blood
Cardiovascular Agents / therapeutic use
Coronary Angiography
Heart Ventricles* / enzymology,  pathology,  physiopathology
Middle Aged
Myocardium / enzymology,  pathology
Practice Guidelines as Topic
Stress, Psychological / complications
Stroke Volume
Takotsubo Cardiomyopathy* / diagnosis,  drug therapy,  etiology,  physiopathology
Treatment Outcome
Ventricular Function, Left
Reg. No./Substance:
0/Biological Markers; 0/Cardiovascular Agents
Comment In:
Clin Cardiol. 2010 Apr;33(4):241-2; author reply 242   [PMID:  20394045 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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