Document Detail


Transgraft infusion of heparin to prevent early thrombosis of expanded PTFE grafts in canine femoral veins.
MedLine Citation:
PMID:  8733867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently we designed an expanded polytetrafluoroethylene (ePTFE)-based local infusion device that delivers therapeutic agents directly through the graft wall in the region adjacent to the upstream anastomosis, thereby achieving a high drug concentration downstream along the graft-blood interface. In this study we evaluated the effects of infusing heparin by this method on graft patency and neointimal hyperplasia in a canine model of femoral vein replacement. Five dogs underwent bilateral femoral vein replacement with the device. In each case one graft was infused with continuous heparin (48 U/kg/day) while the contralateral control graft received phosphate-buffered saline solution for 14 days. All heparin-treated grafts were patent and all control grafts were thrombosed at 14 days. There was no significant difference in systemic activated partial thromboplastin time among samples taken preoperatively, at 48 hours, and at 14 days of implantation (p > 0.5). There was no significant difference in neointimal hyperplasia between the upstream and downstream anastomoses in heparin-treated grafts. These data demonstrate that the transgraft infusion of heparin preserved venous ePTFE graft patency without measurable systemic anticoagulation. Thus this approach may represent an attractive strategy for maintaining patency of synthetic venous grafts.
Authors:
C Chen; J D Hughes; S G Mattar; S R Hanson; A B Lumsden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  10     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-10     Completed Date:  1996-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-55     Citation Subset:  IM    
Affiliation:
Department of Surgery, Emory University School of Medicine, Atlanta, Ga, USA.
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical
Animals
Anticoagulants / administration & dosage*
Blood Vessel Prosthesis*
Dogs
Equipment Design
Femoral Vein / surgery*
Follow-Up Studies
Graft Occlusion, Vascular / prevention & control*
Heparin / administration & dosage*
Hyperplasia
Infusions, Intravenous / instrumentation
Male
Partial Thromboplastin Time
Polytetrafluoroethylene*
Prosthesis Design
Thrombosis / prevention & control*
Tunica Intima / drug effects,  pathology
Vascular Patency
Grant Support
ID/Acronym/Agency:
HL 31469/HL/NHLBI NIH HHS; HL 48667/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anticoagulants; 9002-84-0/Polytetrafluoroethylene; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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