Document Detail


Transglutaminase-dependent antiproliferative and differentiative properties of nimesulide on B16-F10 mouse melanoma cells.
MedLine Citation:
PMID:  19212807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to collect evidences on the role of transglutaminase (TG, E.C.2.3.2.13) in the antineoplastic properties exerted by nimesulide (NMS), a non-steroidal anti-inflammatory drug, on murine B16-F10 melanoma cells. Treatment of melanoma cells with nimesulide produces a considerable reduction of cell proliferation, paralleled by a remarkable decrease of the intracellular concentration of polyamines spermidine and spermine. NMS treatment induces cancer cell differentiation, likely through the observed enhancement of TG and tyrosinase activities and increase of melanin production, well known markers of melanocyte differentiation. The overall results highlight the possibility that nimesulide acts as antineoplastic agent likely through the induction of intracellular TG activity.
Authors:
Angelo Gismondi; Alessandro Lentini; Claudio Tabolacci; Bruno Provenzano; Simone Beninati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-12
Journal Detail:
Title:  Amino acids     Volume:  38     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Affiliation:
Department of Biology, University Tor Vergata, Via della Ricerca Scientifica, 00133, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / drug effects*
Cell Proliferation / drug effects*
Enzyme Activation
Melanins / biosynthesis
Melanoma / drug therapy,  enzymology*,  metabolism,  physiopathology
Melanoma, Experimental
Mice
Polyamines / metabolism
Sulfonamides / pharmacology*
Transglutaminases / metabolism*
Chemical
Reg. No./Substance:
0/Melanins; 0/Polyamines; 0/Sulfonamides; 51803-78-2/nimesulide; EC 2.3.2.13/Transglutaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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