Document Detail


Transgenic swine: expression of human CD39 protects against myocardial injury.
MedLine Citation:
PMID:  22269791     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTROL: 44.7 ± 5.2%, P=0.0025). Our findings demonstrate for the first time that the findings in transgenic mouse models translate to large animal transgenic models and validate the potential to translate CD39 into the clinical arena to attenuate human myocardial ischemia/reperfusion injury.
Authors:
Debra G Wheeler; Matthew E Joseph; Shouvik D Mahamud; William L Aurand; Peter J Mohler; Vincent J Pompili; Karen M Dwyer; Mark B Nottle; Sharon J Harrison; Anthony J F d'Apice; Simon C Robson; Peter J Cowan; Richard J Gumina
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-12
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  52     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-07     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  958-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Antigens, CD / biosynthesis*,  genetics
Apyrase / biosynthesis*,  genetics
Blood Pressure
Coronary Vessels / pathology
Heart Rate
Heart Ventricles / metabolism,  pathology
Humans
Ischemia / metabolism,  pathology
Myocardial Reperfusion Injury / metabolism*,  pathology
Promoter Regions, Genetic
Recombinant Proteins / biosynthesis,  genetics
Swine / genetics*
Grant Support
ID/Acronym/Agency:
HL 094703/HL/NHLBI NIH HHS; HL096038/HL/NHLBI NIH HHS; K08 HL094703/HL/NHLBI NIH HHS; K08 HL094703-03/HL/NHLBI NIH HHS; P01 AI045897/AI/NIAID NIH HHS; P01 AI045897/AI/NIAID NIH HHS; R21 HL096038/HL/NHLBI NIH HHS; R21 HL096038-02/HL/NHLBI NIH HHS; U01 AI066331/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Recombinant Proteins; EC 3.6.1.5/Apyrase; EC 3.6.1.5/CD39 antigen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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