Document Detail


Transgenic mice reveal unexpected diversity of on-off direction-selective retinal ganglion cell subtypes and brain structures involved in motion processing.
MedLine Citation:
PMID:  21677160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On-Off direction-selective retinal ganglion cells (DSGCs) encode the axis of visual motion. They respond strongly to an object moving in a preferred direction and weakly to an object moving in the opposite, "null," direction. Historically, On-Off DSGCs were classified into four subtypes according to their directional preference (anterior, posterior, superior, or inferior). Here, we compare two genetically identified populations of On-Off DSGCs: dopamine receptor 4 (DRD4)-DSGCs and thyrotropin-releasing hormone receptor (TRHR)-DSGCs. We find that although both populations are tuned for posterior motion, they can be distinguished by a variety of physiological and anatomical criteria. First, the directional tuning of TRHR-DSGCs is broader than that of DRD4-DSGCs. Second, whereas both populations project similarly to the dorsal lateral geniculate nucleus, they project differently to the ventral lateral geniculate nucleus and the superior colliculus. Moreover, TRHR-DSGCs, but not DRD4-DSGCs, also project to the zona incerta, a thalamic area not previously known to receive direction-tuned visual information. Our findings reveal unexpected diversity among mouse On-Off DSGC subtypes that uniquely process and convey image motion to the brain.
Authors:
Michal Rivlin-Etzion; Kaili Zhou; Wei Wei; Justin Elstrott; Phong L Nguyen; Ben A Barres; Andrew D Huberman; Marla B Feller
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-16     Completed Date:  2011-08-22     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8760-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / genetics,  physiology
Age Factors
Amacrine Cells / metabolism
Animals
Animals, Newborn
Cholera Toxin / metabolism
Dendrites / physiology
Female
Green Fluorescent Proteins / genetics
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Motion
Motion Perception / physiology*
Orientation / physiology*
Patch-Clamp Techniques / methods
Photic Stimulation / methods
Psychophysics
Receptors, Dopamine D4 / genetics
Receptors, Thyrotropin-Releasing Hormone / genetics
Retina / cytology*
Retinal Ganglion Cells / classification*,  cytology,  physiology*
Vesicular Acetylcholine Transport Proteins / metabolism
Visual Pathways / physiology
Grant Support
ID/Acronym/Agency:
EY019498/EY/NEI NIH HHS; R01 EY013528/EY/NEI NIH HHS; R01 EY013528/EY/NEI NIH HHS; R01 EY013528-11/EY/NEI NIH HHS; R01 EY019498/EY/NEI NIH HHS; R01 EY019498-02/EY/NEI NIH HHS; R01 EY022157/EY/NEI NIH HHS; R01 EY11310/EY/NEI NIH HHS; R21 EY018320/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/DRD4 protein, human; 0/Receptors, Thyrotropin-Releasing Hormone; 0/Slc18a3 protein, mouse; 0/Vesicular Acetylcholine Transport Proteins; 137750-34-6/Receptors, Dopamine D4; 147336-22-9/Green Fluorescent Proteins; 9012-63-9/Cholera Toxin
Comments/Corrections

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