Document Detail


Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids.
MedLine Citation:
PMID:  14765186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammals cannot naturally produce omega-3 (n-3) fatty acids--beneficial nutrients found mainly in fish oil--from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply. Here we show that mice engineered to carry a fat-1 gene from the roundworm Caenorhabditis elegans can add a double bond into an unsaturated fatty-acid hydrocarbon chain and convert n-6 to n-3 fatty acids. This results in an abundance of n-3 and a reduction in n-6 fatty acids in the organs and tissues of these mice, in the absence of dietary n-3. As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs.
Authors:
Jing X Kang; Jingdong Wang; Lin Wu; Zhao B Kang
Related Documents :
19369246 - Age-related decline in rod phototransduction sensitivity in rhesus monkeys fed an n-3 f...
15820606 - Dietary fatty acids intake: possible role in cognitive decline and dementia.
3781746 - Stability of plasma fatty acids at -20 degrees c and its relationship to antioxidants.
11837986 - N-3 polyunsaturated fatty acids and cardiovascular diseases.
9735216 - Interphase transport of benzoic acid in emulsions.
11992786 - Identification of potent and selective oxytocin antagonists. part 1: indole and benzofu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  427     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-06     Completed Date:  2004-02-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  504     Citation Subset:  IM    
Affiliation:
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. kang.jing@mgh.harvard.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Composition
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins / genetics,  metabolism*
Dietary Fats / administration & dosage,  pharmacology
Disease Susceptibility
Fatty Acid Desaturases / genetics,  metabolism*
Fatty Acids, Omega-3 / administration & dosage,  metabolism*,  pharmacology
Fatty Acids, Omega-6 / administration & dosage,  metabolism*,  pharmacology
Food
Food Industry / trends
Mice
Mice, Transgenic
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/fat-1 protein, C elegans; EC 1.14.19.-/Fatty Acid Desaturases
Comments/Corrections
Erratum In:
Nature. 2004 Feb 19;427(6976):698

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stress propagation: getting to the bottom of a granular medium.
Next Document:  Mixing, volatile loss and compositional change during impact-driven accretion of the Earth.