Document Detail

Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids.
MedLine Citation:
PMID:  14765186     Owner:  NLM     Status:  MEDLINE    
Mammals cannot naturally produce omega-3 (n-3) fatty acids--beneficial nutrients found mainly in fish oil--from the more abundant omega-6 (n-6) fatty acids and so they must rely on a dietary supply. Here we show that mice engineered to carry a fat-1 gene from the roundworm Caenorhabditis elegans can add a double bond into an unsaturated fatty-acid hydrocarbon chain and convert n-6 to n-3 fatty acids. This results in an abundance of n-3 and a reduction in n-6 fatty acids in the organs and tissues of these mice, in the absence of dietary n-3. As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs.
Jing X Kang; Jingdong Wang; Lin Wu; Zhao B Kang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  427     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-06     Completed Date:  2004-02-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  504     Citation Subset:  IM    
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
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MeSH Terms
Body Composition
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins / genetics,  metabolism*
Dietary Fats / administration & dosage,  pharmacology
Disease Susceptibility
Fatty Acid Desaturases / genetics,  metabolism*
Fatty Acids, Omega-3 / administration & dosage,  metabolism*,  pharmacology
Fatty Acids, Omega-6 / administration & dosage,  metabolism*,  pharmacology
Food Industry / trends
Mice, Transgenic
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/fat-1 protein, C elegans; EC 1.14.19.-/Fatty Acid Desaturases
Erratum In:
Nature. 2004 Feb 19;427(6976):698

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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