Document Detail

Transgenic epigenetics: using transgenic organisms to examine epigenetic phenomena.
MedLine Citation:
PMID:  22567397     Owner:  NLM     Status:  In-Data-Review    
Non-model organisms are generally more difficult and/or time consuming to work with than model organisms. In addition, epigenetic analysis of model organisms is facilitated by well-established protocols, and commercially-available reagents and kits that may not be available for, or previously tested on, non-model organisms. Given the evolutionary conservation and widespread nature of many epigenetic mechanisms, a powerful method to analyze epigenetic phenomena from non-model organisms would be to use transgenic model organisms containing an epigenetic region of interest from the non-model. Interestingly, while transgenic Drosophila and mice have provided significant insight into the molecular mechanisms and evolutionary conservation of the epigenetic processes that target epigenetic control regions in other model organisms, this method has so far been under-exploited for non-model organism epigenetic analysis. This paper details several experiments that have examined the epigenetic processes of genomic imprinting and paramutation, by transferring an epigenetic control region from one model organism to another. These cross-species experiments demonstrate that valuable insight into both the molecular mechanisms and evolutionary conservation of epigenetic processes may be obtained via transgenic experiments, which can then be used to guide further investigations and experiments in the species of interest.
Lori A McEachern
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Publication Detail:
Type:  Journal Article     Date:  2012-03-27
Journal Detail:
Title:  Genetics research international     Volume:  2012     ISSN:  2090-3162     ISO Abbreviation:  Genet Res Int     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101571472     Medline TA:  Genet Res Int     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  689819     Citation Subset:  -    
Department of Biology, Dalhousie University, Halifax, NS, Canada B3H 4R2.
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