Document Detail

Transgenic animal models of cardiovascular disease.
MedLine Citation:
PMID:  1369120     Owner:  NLM     Status:  MEDLINE    
Transgenic experimentation has become a crucial part of hypertension and atherosclerosis research, and is growing more important in several other areas of cardiovascular disease. It has recently made a particular contribution to understanding the role of the renin-angiotensin system in controlling hypertension. The study of blood pressure regulation, cardiac hypertrophy, atherogenesis and thrombosis are also benefiting from the transgenic approach.
G Barrett; J J Mullins
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  3     ISSN:  0958-1669     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  637-40     Citation Subset:  B    
Centre for Genome Research, University of Edinburgh, UK.
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MeSH Terms
Animals, Genetically Modified*
Apolipoprotein A-I / metabolism
Arteriosclerosis / genetics,  physiopathology
Blood Pressure
Cardiomegaly / genetics,  physiopathology
Cardiovascular Diseases / genetics,  physiopathology*
Cholesterol, HDL / blood
Disease Models, Animal
Hypertension / genetics,  physiopathology
Mice, Transgenic
Renin / genetics
Renin-Angiotensin System / genetics
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Cholesterol, HDL; EC

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