Document Detail


Transgenic RNAi applications in the mouse.
MedLine Citation:
PMID:  20699151     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within the past 10 years, RNA interference has emerged as a powerful experimental tool as it allows rapid gene function analysis. Unique features such as reversibility of gene silencing and simultaneous targeting of several genes characterize the approach. In this chapter, transgenic RNAi techniques in reverse mouse genetics are discussed and protocols are provided.
Authors:
Jost Seibler; Frieder Schwenk
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  477     ISSN:  1557-7988     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-86     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Affiliation:
TaconicArtemis GmbH, Cologne, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Silencing / physiology*
Mice
Mice, Transgenic
RNA Interference / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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