Document Detail

Transgene-encoded antiphosphorylcholine (T15+) antibodies protect CBA/N (xid) mice against infection with Streptococcus pneumoniae but not Trichinella spiralis.
MedLine Citation:
PMID:  8168926     Owner:  NLM     Status:  MEDLINE    
Immunodeficient CBA/N (xid) mice are highly susceptible to Streptococcus pneumoniae infection. Previous studies indicated that this susceptibility may be attributed to the lack of antibodies to phosphorylcholine (PC) in the circulation of these animals. We now provide direct proof that when these mice are genetically manipulated to produce significant amounts of circulating anti-PC immunoglobulin G antibodies of the T15 idiotype, they can be protected against a lethal challenge with S. pneumoniae. Transgenic mice were also used to investigate whether the transgene-encoded antibodies could protect the animals against another PC-bearing microorganism, Trichinella spiralis; in this case, there was no protection. These results were further supported by experiments with CFW mice which had been immunized to produce high levels of anti-PC antibodies but which were found to be just as susceptible to T. spiralis infection as nonimmunized animals.
P L Lim; W F Choy; S T Chan; D T Leung; S S Ng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  62     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-02     Completed Date:  1994-06-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1658-61     Citation Subset:  IM    
Clinical Immunology Unit, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T.
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MeSH Terms
Antibodies / genetics,  immunology*
Mice, Inbred BALB C
Mice, Inbred CBA
Mice, Transgenic
Phosphorylcholine / immunology*
Pneumococcal Infections / immunology*
Trichinella spiralis*
Trichinellosis / immunology*
Reg. No./Substance:
0/Antibodies; 107-73-3/Phosphorylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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