| Transfusions of CPDA-1 red blood cells stored for up to 28 days decrease donor exposures in very low-birth-weight premature infants. | |
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MedLine Citation:
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PMID: 16359417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of this research was to study the safety and the efficacy of transfusing citrate-phosphate-adenine anticoagulant-preservative (CPDA-1) RBC stored for up to 28 days to reduce donor exposures in premature infants. A prospective randomized two-group study was conducted with very low-birth-weight premature infants that received at least one RBC transfusion during hospital stay. Neonates randomly assigned to Group 1 (26 infants) were transfused with CPDA-1 RBC stored for up to 28 days; those assigned to Group 2 (26 infants) received CPDA-1 RBC stored for up to 3 days. Demographic and transfusion-related data were collected. Neonates from both groups showed similar demographics and clinical characteristics. The number of transfusions per infant transfused was 4.4 +/- 4.0 in Group 1 and 4.2 +/- 3.1 in Group 2, and the number of donors per infant transfused was 1.5 +/- 0.8 (Group 1) and 4.3 +/- 3.4 (Group 2), P < 0.001. RBC transfusions containing 29.7 +/- 18.3 mmol L(-1) of potassium (RBC stored for up to 28 days) did not cause clinical or biochemical changes and reduced donor exposures by 70.2%, compared to transfusions containing 19.8 +/- 12.3 mmol L(-1) of potassium (RBC stored for up to 3 days), P < 0.001. In conclusion, RBC stored for up to 28 days safely reduced donor exposures in premature infants. |
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Authors:
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D H Fernandes da Cunha; A M Nunes Dos Santos; B I Kopelman; K N Areco; R Guinsburg; C de Araújo Peres; A K Chiba; S T Kuwano; C C N Terzian; J O Bordin |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transfusion medicine (Oxford, England) Volume: 15 ISSN: 0958-7578 ISO Abbreviation: Transfus Med Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-19 Completed Date: 2006-05-26 Revised Date: 2008-07-31 |
Medline Journal Info:
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Nlm Unique ID: 9301182 Medline TA: Transfus Med Country: England |
Other Details:
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Languages: eng Pagination: 467-73 Citation Subset: IM |
Affiliation:
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Division of Neonatal Medicine, Department of Pediatrics, Hematology and Transfusion Medicine Service, Department of Biostatistics, Federal University of São Paulo, São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenine* Blood Chemical Analysis Blood Donors Blood Preservation / methods* Citrates* Consumer Product Safety Erythrocyte Transfusion / methods*, standards Glucose* Humans Infant, Low Birth Weight* Infant, Newborn Infant, Premature* Phosphates* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/CPDA solutions; 0/Citrates; 0/Phosphates; 50-99-7/Glucose; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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