| Transfusion therapy in sickle cell disease patients: methods and acute indications. | |
| | |
MedLine Citation:
|
PMID: 8120439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Management of transfusion therapy in sickle cell disease patients with acute complications is often made difficult because of confusing indications, a variety of methods, disparate goals, and varying needs for maintenance transfusion. In priapism, acute chest syndrome, many major surgical procedures, toxemia of pregnancy, and cerebrovascular accidents, the target hemoglobin A level should be made as close to 100% as possible by mechanized red blood cell exchange. If mechanized exchange is unavailable, manual exchange should be instituted. Hemoglobin A should be maintained at greater than 60% to 70% by periodic simple transfusion until patients are fully recovered. Stroke patients should undergo maintenance transfusions for at least 3 years and perhaps 5 to 12 years. Physicians and patients should be aware of the transfusion-related risks of hepatitis and HIV infection. Alloimmunization and iron overload should be minimized in patients requiring frequent transfusions and chelation therapy should be utilized for iron overload. |
| | |
Authors:
|
L C Campbell; G Von Burton; R F Holcombe |
Related Documents
:
|
10413279 - The effect of unmodified or prestorage white cell-reduced allogeneic red cell transfusi... 3830529 - Hypersplenism and splenectomy in lymphoproliferative and myeloproliferative disorders. 18503589 - Eculizumab, a terminal complement inhibitor, improves anaemia in patients with paroxysm... 7509209 - A cautionary note regarding hydroxyurea in sickle cell disease. 1123439 - Haematological changes in active chronic hepatitis with reference to the role of the sp... 7361719 - Serum immunoglobulin levels in patients having sickle cell syndromes. 3346689 - The effect of age of disease onset on neuropsychological performance in parkinson's dis... 21709949 - Gastroesophageal reflux disease and vocal disturbances. 21270119 - Portal cholangiopathy: radiological classification and natural history. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society Volume: 145 ISSN: 0024-6921 ISO Abbreviation: J La State Med Soc Publication Date: 1993 Dec |
Date Detail:
|
Created Date: 1994-04-07 Completed Date: 1994-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7505618 Medline TA: J La State Med Soc Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 515-21 Citation Subset: IM |
Affiliation:
|
Dept of Medicine, Louisiana State University School of Medicine-Shreveport. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Sickle Cell
/
complications,
therapy* Blood Transfusion* / adverse effects, methods Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fine needle aspiration in head and neck surgery.
Next Document: Hypereosinophylic syndrome in a bronchial asthmatic.