| Transfusion-related acute lung injury (TRALI): a review of investigations by the National Tissue Typing Laboratory of cases reported in New Zealand since June 2004. | |
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MedLine Citation:
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PMID: 18574508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To review investigations of reported cases of Transfusion-Related Acute Lung Injury (TRALI) performed by the National Tissue Typing laboratory since 2004. METHOD: Donors associated with reported cases of TRALI are recalled for white cell antibody tests. A donor is implicated if found to have neutrophil or HLA antibodies with specificity against one of the recipient's HLA antigens, or a positive white cell crossmatch. A retrospective review of investigations performed by the Tissue Typing Laboratory on TRALI cases from June 2004 to June 2007 was undertaken. RESULTS: Seventeen cases of TRALI had tests performed by the Tissue Typing Laboratory over the 3-year period. A total of 67 donors were tested. Twenty-nine donors had a positive HLA-antibody screen and the majority of these were female (86%, with fresh frozen plasma (FFP) the commonest component type (41%). In 15 (88%) cases, HLA antibodies were found in donor sera and nine of these had specificity against patient HLA antigen or a positive crossmatch. CONCLUSION: Preliminary data on TRALI investigations concur with overseas studies. Raising awareness of this hazard of transfusion and a consistent approach in investigation of TRALI will allow us to gain further insight into this complication in New Zealand and consequently explore strategies to prevent such adverse transfusion reactions. |
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Authors:
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Paul Dunn; Dorothy Dinesh |
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Publication Detail:
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Type: Journal Article Date: 2008-06-20 |
Journal Detail:
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Title: The New Zealand medical journal Volume: 121 ISSN: 1175-8716 ISO Abbreviation: N. Z. Med. J. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-24 Completed Date: 2008-07-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0401067 Medline TA: N Z Med J Country: New Zealand |
Other Details:
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Languages: eng Pagination: 42-7 Citation Subset: IM |
Affiliation:
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New Zealand Blood Service, Private Bag 7904, Wellington 6021, New Zealand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Antigen-Antibody Reactions Blood Donors / statistics & numerical data* Blood Group Incompatibility / epidemiology* Blood Grouping and Crossmatching / statistics & numerical data* Blood Transfusion / adverse effects, statistics & numerical data* Female Humans Laboratories / statistics & numerical data Lung Diseases / epidemiology*, etiology Lung Injury Male New Zealand / epidemiology Primary Prevention / statistics & numerical data Retrospective Studies Risk Management / statistics & numerical data |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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