Document Detail

Transfusion-related acute lung injury (TRALI): a review of investigations by the National Tissue Typing Laboratory of cases reported in New Zealand since June 2004.
MedLine Citation:
PMID:  18574508     Owner:  NLM     Status:  MEDLINE    
AIM: To review investigations of reported cases of Transfusion-Related Acute Lung Injury (TRALI) performed by the National Tissue Typing laboratory since 2004. METHOD: Donors associated with reported cases of TRALI are recalled for white cell antibody tests. A donor is implicated if found to have neutrophil or HLA antibodies with specificity against one of the recipient's HLA antigens, or a positive white cell crossmatch. A retrospective review of investigations performed by the Tissue Typing Laboratory on TRALI cases from June 2004 to June 2007 was undertaken. RESULTS: Seventeen cases of TRALI had tests performed by the Tissue Typing Laboratory over the 3-year period. A total of 67 donors were tested. Twenty-nine donors had a positive HLA-antibody screen and the majority of these were female (86%, with fresh frozen plasma (FFP) the commonest component type (41%). In 15 (88%) cases, HLA antibodies were found in donor sera and nine of these had specificity against patient HLA antigen or a positive crossmatch. CONCLUSION: Preliminary data on TRALI investigations concur with overseas studies. Raising awareness of this hazard of transfusion and a consistent approach in investigation of TRALI will allow us to gain further insight into this complication in New Zealand and consequently explore strategies to prevent such adverse transfusion reactions.
Paul Dunn; Dorothy Dinesh
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Publication Detail:
Type:  Journal Article     Date:  2008-06-20
Journal Detail:
Title:  The New Zealand medical journal     Volume:  121     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
New Zealand Blood Service, Private Bag 7904, Wellington 6021, New Zealand.
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MeSH Terms
Acute Disease
Antigen-Antibody Reactions
Blood Donors / statistics & numerical data*
Blood Group Incompatibility / epidemiology*
Blood Grouping and Crossmatching / statistics & numerical data*
Blood Transfusion / adverse effects,  statistics & numerical data*
Laboratories / statistics & numerical data
Lung Diseases / epidemiology*,  etiology
Lung Injury
New Zealand / epidemiology
Primary Prevention / statistics & numerical data
Retrospective Studies
Risk Management / statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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