Document Detail


Transfusion-related acute lung injury (TRALI): a review of investigations by the National Tissue Typing Laboratory of cases reported in New Zealand since June 2004.
MedLine Citation:
PMID:  18574508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To review investigations of reported cases of Transfusion-Related Acute Lung Injury (TRALI) performed by the National Tissue Typing laboratory since 2004. METHOD: Donors associated with reported cases of TRALI are recalled for white cell antibody tests. A donor is implicated if found to have neutrophil or HLA antibodies with specificity against one of the recipient's HLA antigens, or a positive white cell crossmatch. A retrospective review of investigations performed by the Tissue Typing Laboratory on TRALI cases from June 2004 to June 2007 was undertaken. RESULTS: Seventeen cases of TRALI had tests performed by the Tissue Typing Laboratory over the 3-year period. A total of 67 donors were tested. Twenty-nine donors had a positive HLA-antibody screen and the majority of these were female (86%, with fresh frozen plasma (FFP) the commonest component type (41%). In 15 (88%) cases, HLA antibodies were found in donor sera and nine of these had specificity against patient HLA antigen or a positive crossmatch. CONCLUSION: Preliminary data on TRALI investigations concur with overseas studies. Raising awareness of this hazard of transfusion and a consistent approach in investigation of TRALI will allow us to gain further insight into this complication in New Zealand and consequently explore strategies to prevent such adverse transfusion reactions.
Authors:
Paul Dunn; Dorothy Dinesh
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Publication Detail:
Type:  Journal Article     Date:  2008-06-20
Journal Detail:
Title:  The New Zealand medical journal     Volume:  121     ISSN:  1175-8716     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
New Zealand Blood Service, Private Bag 7904, Wellington 6021, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antigen-Antibody Reactions
Blood Donors / statistics & numerical data*
Blood Group Incompatibility / epidemiology*
Blood Grouping and Crossmatching / statistics & numerical data*
Blood Transfusion / adverse effects,  statistics & numerical data*
Female
Humans
Laboratories / statistics & numerical data
Lung Diseases / epidemiology*,  etiology
Lung Injury
Male
New Zealand / epidemiology
Primary Prevention / statistics & numerical data
Retrospective Studies
Risk Management / statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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