Document Detail


Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature.
MedLine Citation:
PMID:  16999757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transfusion-related acute lung injury (TRALI) is increasingly recognized as a major complication of transfusion therapy; it was the leading cause of transfusion-related fatalities in the United States in 2003. Most cases of TRALI that have been reported are in adult patients. We present two cases of TRALI that occurred in children and review the existing literature of paediatric TRALI. The paediatric TRALI case reports highlight two laboratory findings that can help in the diagnosis of TRALI: transient leucopenia and an elevated pulmonary oedema fluid/plasma protein ratio. These two simple diagnostic tests can help rule out other diagnoses and add confidence to the clinical diagnosis of TRALI. Finally, our first case also highlights the potential danger of directed maternal blood donations, which may increase the risk of paediatric TRALI.
Authors:
G D Church; C Price; R Sanchez; M R Looney
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Transfusion medicine (Oxford, England)     Volume:  16     ISSN:  0958-7578     ISO Abbreviation:  Transfus Med     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-26     Completed Date:  2006-11-07     Revised Date:  2008-07-31    
Medline Journal Info:
Nlm Unique ID:  9301182     Medline TA:  Transfus Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143-0130, USA. gwynnechurch@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Donors
Blood Proteins / analysis
Blood Transfusion / adverse effects*
Child
Female
Histocompatibility / immunology
Histocompatibility Testing / methods
Humans
Leukopenia / etiology
Pulmonary Edema / etiology
Respiratory Distress Syndrome, Adult / complications,  diagnosis,  etiology*
Chemical
Reg. No./Substance:
0/Blood Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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