Document Detail

Transfusion of platelet components prepared with photochemical pathogen inactivation treatment during a Chikungunya virus epidemic in Ile de La Réunion.
MedLine Citation:
PMID:  19309473     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: During the Chikungunya virus (CHIKV) epidemic on Ile de La Réunion, France, more than 30% of 750,000 inhabitants were infected. Local blood donation was suspended to prevent transfusion-transmitted infection (TT-CHIKV). To sustain the availability of platelet (PLT) components, the Etablissement Français du Sang implemented universal pathogen inactivation (INTERCEPT, Cerus Europe BV) of PLT components (CPAs). The study assessed the safety of PLT components treated with pathogen inactivation transfused in routine clinical practice. STUDY DESIGN AND METHODS: This was a retrospective observational study using patient medical records and the AFSSAPS hemovigilance database (eFIT) to identify TT-CHIKV and adverse events (AEs) classified as acute transfusion reactions (ATRs) to PLT components prepared with pathogen inactivation. RESULTS: During 1 year, 1950 INTERCEPT-CPAs were transfused to 335 adult, 51 pediatric, and 41 infant patients. Nineteen AEs were observed in 15 patients and 10 were classified as ATRs. Eight ATRs occurred in 6 pediatric hematology-oncology patients. No ATRs were observed in infants. The most frequently reported signs and symptoms were Grade 1 urticaria, itching, chills, fever, and anxiety. No cases of transfusion-related acute lung injury, TT-sepsis, or TT-CHIKV were detected. CONCLUSIONS: INTERCEPT-CPAs were well tolerated in a broad range of patients, including infants. ATR incidence was low and when present ATRs were of mild severity.
Patrice Rasonglès; Marie France Angelini-Tibert; Philip Simon; Caroline Currie; Herve Isola; Daniel Kientz; Marc Slaedts; Michele Jacquet; David Sundin; Lily Lin; Laurence Corash; Jean Pierre Cazenave
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-27
Journal Detail:
Title:  Transfusion     Volume:  49     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-91     Citation Subset:  IM    
EFS Ile de La Réunion, St Denis, Ile de La Réunion, France.
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MeSH Terms
Aged, 80 and over
Alphavirus Infections / epidemiology,  prevention & control*
Blood Donors
Chikungunya virus / drug effects*,  radiation effects*
Child, Preschool
France / epidemiology
Infant, Newborn
Middle Aged
Platelet Transfusion / adverse effects*
Psoralens / pharmacology
Retrospective Studies
Ultraviolet Rays
Reg. No./Substance:
0/Psoralens; 0/S-59, psoralen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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