| Transfusion independence in patients with myelodysplastic syndromes: impact on outcomes and quality of life. | |
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MedLine Citation:
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PMID: 16607649 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anemia is the most common cytopenia associated with myelodysplastic syndromes (MDS). Current management relies on frequent red blood cell (RBC) transfusions and erythroid growth factors to alleviate symptoms. However, the dependence of patients with MDS on repeated RBC transfusions often results in significant clinical and economic consequences, poorer outcomes, and diminished health-related quality of life. In addition, the intensity and duration of RBC transfusion dependence can influence responses to treatment after disease progression. Erythropoietic growth factors may alleviate the need for RBC transfusions in some patients with MDS, although only a minority of patients experience responses. Emerging treatment strategies to reduce or eliminate the need for RBC transfusions in patients with MDS include immunomodulating drugs, immunosuppressive therapy, and differentiating agents. The immunomodulating drug lenalidomide in patients who have MDS with 5q deletion is unique among emerging approaches, in that cytogenetic remitting activity and durable erythroid responses have been achieved. Newer treatments have the potential to improve the care of patients with MDS by alleviating the clinical, economic, and quality-of-life consequences of long-term RBC transfusion dependence. |
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Authors:
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Lodovico Balducci |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Cancer Volume: 106 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-03 Completed Date: 2006-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 2087-94 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2006 American Cancer Society |
Affiliation:
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Department of Interdisciplinary Oncology, Geriatric Section, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612-9497, USA. balducci@moffitt.usf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia / diagnosis, mortality, therapy Disease Progression Erythrocyte Transfusion / methods* Female Humans Immunosuppressive Agents / therapeutic use Male Middle Aged Myelodysplastic Syndromes / diagnosis*, mortality, therapy* Prognosis Quality of Life* Risk Assessment Severity of Illness Index Sickness Impact Profile Survival Analysis Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
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