Document Detail

Transfusion-associated necrotizing enterocolitis: evidence and uncertainty.
MedLine Citation:
PMID:  22864004     Owner:  NLM     Status:  MEDLINE    
Transfusion-associated necrotizing enterocolitis (TANEC) has been described as necrotizing enterocolitis (NEC) that arises within 48 hours of a blood transfusion. It has been shown to be associated with 25% to 35% of NEC cases in recent studies. Evidence related to TANEC is limited to observational, retrospective studies. Infants who develop TANEC tend to be smaller, born preterm, more severely ill, and develop NEC after 30 days of age. Evidence in 2 studies support holding feedings during transfusion to protect the preterm gut from the cascade of events that lead to NEC, but higher quality research, including prospective randomized controlled trials, is needed to evaluate the effect of feeding on TANEC.
Sheila M Gephart
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in neonatal care : official journal of the National Association of Neonatal Nurses     Volume:  12     ISSN:  1536-0911     ISO Abbreviation:  Adv Neonatal Care     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-06     Completed Date:  2012-12-11     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  101125644     Medline TA:  Adv Neonatal Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  232-6     Citation Subset:  IM    
College of Nursing, University of Arizona, Tucson, USA.
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MeSH Terms
Blood Transfusion / adverse effects*,  methods
Enteral Nutrition / adverse effects*,  methods
Enterocolitis, Necrotizing / etiology,  therapy*
Evidence-Based Practice
Infant, Newborn
Grant Support
1F31NR012333-01A1/NR/NINR NIH HHS; F31 NR012333/NR/NINR NIH HHS

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