| Transfusion-associated graft-versus-host disease. | |
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MedLine Citation:
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PMID: 18544121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of transfusion of cellular blood components producing a graft-versus-host clinical picture with concomitant bone marrow aplasia. The disease is fulminant and rapidly fatal in the majority of patients. TA-GvHD is caused by transfused blood-derived, alloreactive T lymphocytes that attack host tissue, including bone marrow with resultant bone marrow failure. Human leucocyte antigen similarity between the transfused lymphocytes and the host, often in conjunction with host immunosuppression, allows tolerance of the grafted lymphocytes to survive the host immunological response. Any blood component containing viable T lymphocytes can cause TA-GvHD, with fresher components more likely to have intact cells and, thus, able to cause disease. Treatment is generally not helpful, while prevention, usually via irradiation of blood components given to susceptible recipients, is the key to obviating TA-GvHD. Newer methods, such as pathogen inactivation, may play an important role in the future. |
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Authors:
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D M Dwyre; P V Holland |
Publication Detail:
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Type: Journal Article; Review Date: 2008-06-09 |
Journal Detail:
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Title: Vox sanguinis Volume: 95 ISSN: 1423-0410 ISO Abbreviation: Vox Sang. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-13 Completed Date: 2008-10-08 Revised Date: 2009-10-22 |
Medline Journal Info:
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Nlm Unique ID: 0413606 Medline TA: Vox Sang Country: England |
Other Details:
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Languages: eng Pagination: 85-93 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of California Davis Medical Center, Sacramento, CA 95817, USA. denis.dwyre@ucdmc.ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood / radiation effects Blood Transfusion / adverse effects* Bone Marrow / immunology, pathology Chick Embryo Cytokines / secretion Diarrhea / etiology Fever / etiology Graft vs Host Disease / diagnosis, etiology*, immunology, pathology, prevention & control Humans Immunocompetence Liver Diseases / etiology Lymphocyte Depletion / methods Lymphocyte Transfusion / adverse effects Mice Pancytopenia / etiology, immunology, prevention & control T-Lymphocyte Subsets / immunology, radiation effects, secretion, transplantation* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
| Comments/Corrections | |
Comment In:
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Vox Sang. 2009 Nov;97(4):358; author reply 359
[PMID:
19840352
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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