| Transfusion-associated chronic cutaneous graft-versus-host disease. | |
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MedLine Citation:
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PMID: 7615879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transfusion-associated graft-versus-host disease (TAGVHD) occurs in immunocompromised persons who receive nonirradiated blood products containing immunologically competent donor lymphocytes. TAGVHD occurs almost exclusively as an acute illness and has a very high mortality rate. We describe a patient with a long history of non-Hodgkin's lymphoma in whom acute TAGVHD developed after transfusion of packed red blood cells from two unrelated donors. TAGVHD developed despite pretreatment of the transfused units with white blood cell filters. The patient survived and subsequently had clinical manifestations typical of chronic cutaneous graft-versus-host disease. HLA phenotyping studies suggested that elements from both transfusion donors engrafted. TAGVHD is a rare but probably underdiagnosed disorder that, although usually fatal, may evolve into chronic graft-versus-host disease. Treatment of blood products with white blood cell filters does not appear adequate to prevent TAGVHD. |
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Authors:
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R J Hull; R A Bray; C Hillyer; R A Swerlick |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 33 ISSN: 0190-9622 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-08-22 Completed Date: 1995-08-22 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 327-32 Citation Subset: IM |
Affiliation:
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Department of Medicine, Emory University School of Medicine, GA 30322, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Transfusion / adverse effects* Chronic Disease Female Graft vs Host Disease / etiology*, pathology Humans Skin Diseases / etiology*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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