Document Detail


Transfusion-associated microchimerism: the hybrid within.
MedLine Citation:
PMID:  23102759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microchimerism, the coexistence of genetically disparate populations of cells in a receptive host, is well described in both clinical and physiological settings, including transplantation and pregnancy. Microchimerism can also occur after allogeneic blood transfusion in traumatically injured patients, where donor cells have been observed decades after transfusion. To date, transfusion-associated microchimerism (TA-MC) appears confined to this clinical subset, most likely due to the immune perturbations that occur after severe trauma that allow foreign donor cells to survive. Transfusion-associated microchimerism appears to be unaffected by leukoreduction and has been documented after transfusion with an array of blood products. The only significant predictor of TA-MC to date is the age of red cells, with fresher units associated with higher risk. Thus far, no adverse clinical effect has been observed in limited studies of TA-MC. There are, however, hypothesized links to transfusion-associated graft vs host disease that may be unrecognized and consequently underreported. Microchimerism in other settings has gained increasing attention owing to a plausible link to autoimmune diseases, as well as its diagnostic and therapeutic potential vis-a-vis antenatal testing and adoptive immunotherapy, respectively. Furthermore, microchimerism provides a tool to further our understanding of immune tolerance and regulation.
Authors:
Evan M Bloch; Rachael P Jackman; Tzong-Hae Lee; Michael P Busch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-24
Journal Detail:
Title:  Transfusion medicine reviews     Volume:  27     ISSN:  1532-9496     ISO Abbreviation:  Transfus Med Rev     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-23     Revised Date:  2014-04-29    
Medline Journal Info:
Nlm Unique ID:  8709027     Medline TA:  Transfus Med Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / etiology
Blood Transfusion / adverse effects
Cell Lineage
Chimerism*
Female
Fetofetal Transfusion / immunology
Fetomaternal Transfusion
Graft vs Host Disease / etiology
Humans
Immune Tolerance
Immunotherapy, Adoptive
Leukocyte Reduction Procedures
Male
Pregnancy
Prenatal Diagnosis
Risk Factors
Transplantation Chimera* / genetics
Wounds and Injuries / immunology,  therapy
Grant Support
ID/Acronym/Agency:
P30 DK026743/DK/NIDDK NIH HHS; R01 HL-083388-01A1/HL/NHLBI NIH HHS; R01 HL083388/HL/NHLBI NIH HHS
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