| Transfusion-Associated Microchimerism: The Hybrid Within. | |
| | |
MedLine Citation:
|
PMID: 23102759 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Microchimerism, the coexistence of genetically disparate populations of cells in a receptive host, is well described in both clinical and physiological settings, including transplantation and pregnancy. Microchimerism can also occur after allogeneic blood transfusion in traumatically injured patients, where donor cells have been observed decades after transfusion. To date, transfusion-associated microchimerism (TA-MC) appears confined to this clinical subset, most likely due to the immune perturbations that occur after severe trauma that allow foreign donor cells to survive. Transfusion-associated microchimerism appears to be unaffected by leukoreduction and has been documented after transfusion with an array of blood products. The only significant predictor of TA-MC to date is the age of red cells, with fresher units associated with higher risk. Thus far, no adverse clinical effect has been observed in limited studies of TA-MC. There are, however, hypothesized links to transfusion-associated graft vs host disease that may be unrecognized and consequently underreported. Microchimerism in other settings has gained increasing attention owing to a plausible link to autoimmune diseases, as well as its diagnostic and therapeutic potential vis-a-vis antenatal testing and adoptive immunotherapy, respectively. Furthermore, microchimerism provides a tool to further our understanding of immune tolerance and regulation. |
| | |
Authors:
|
Evan M Bloch; Rachael P Jackman; Tzong-Hae Lee; Michael P Busch |
Related Documents
:
|
13706099 - Prothrombin time. determination by a whole blood micro-method for control of anticoagul... 23505939 - Ensuring patient safety blood transfusision. 20549389 - A simple and efficient method for dna purification from samples of highly clotted blood. 22762729 - Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may ... 1420919 - Penetration of macromolecules into contracted blood clot. 23278449 - Blood utilization in patients with burn injury and association with clinical outcomes. 18965289 - Simultaneous flow-injection determination of chlorpromazine and promethazine by photoch... 20967169 - Determining the volume of blood required for the correction of foetal anaemia by intrau... 11851969 - Serial sonographic findings of four fetuses with homozygous alpha-thalassemia-1 from 21... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-23 |
Journal Detail:
|
Title: Transfusion medicine reviews Volume: - ISSN: 1532-9496 ISO Abbreviation: Transfus Med Rev Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709027 Medline TA: Transfus Med Rev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Blood Systems Research Institute, San Francisco, CA. Electronic address: ebloch@bloodsystems.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-Term Control of Refractory Hemorrhagic Radiation Proctitis With Ozone Therapy.
Next Document: Detection of Neospora caninum in wild carnivorans in Great Britain.