Document Detail


Transforming growth factor signalling: a common pathway in pulmonary arterial hypertension and systemic sclerosis.
MedLine Citation:
PMID:  21736678     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pulmonary arterial hypertension (PAH) is a clinical condition characterised by the presence of precapillary pulmonary hypertension (PH). Included within the subcategorisation of PAH are heritable (HPAH) and PAH associated various conditions (APAH) including systemic sclerosis (SSc). The pathogenesis of HPAH and SSc has been linked to both a genetic predisposition and epigenetic factors. TGF-β superfamily signalling has also been implicated in the development of these conditions. In this review, we discuss the role of genetic predisposition, epigenetic factors along with dysregulation in TGF-β superfamily signalling in the pathogenesis of PAH and SSc.
Authors:
N Hatton; T Frech; B Smith; A Sawitzke; M B Scholand; B Markewitz
Related Documents :
17154428 - Fatal ischemic stroke related to nonpermissive peripheral artery access for percutaneou...
22034598 - Severe pulmonary artery hypertension following intracardiac repair of tetralogy of fall...
19017018 - Aortic valve replacement following coronary artery bypass grafting using bilateral inte...
24483838 - Progressive jugular vein thrombosis in cutaneous extramedullary plasmacytoma.
16750728 - Wedging the pulmonary artery catheter: changes in left atrial and pulmonary artery pres...
11308208 - A new repair for anomalous left coronary artery.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  65 Suppl 172     ISSN:  1742-1241     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-43     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Division of Respiratory, Critical Care and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA Division of Rheumatology, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categori...
Next Document:  Inflammatory polyps following successful HLA-matched cord blood transplantation in a patient with X-...