Document Detail


Transforming growth factor-beta3-induced Smad signaling regulates actin reorganization during chondrogenesis of chick leg bud mesenchymal cells.
MedLine Citation:
PMID:  19479909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endochondral ossification is characterized by a significant interdependence between cell shape and cytoskeletal organization that accompanies the onset of chondrogenic signaling. However, the mechanisms mediating these interactions have not been well studied. Here, treatment with transforming growth factor (TGF)-beta3 at a later stage of chondrogenesis led to activation of Smad-2 signaling and the formation of intense stress fibers, which resulted in suppressing chondrogenic differentiation of leg bud mesenchymal cells. Moreover, specific siRNA knockdown of Smad-2 reduced TGF-beta3-induced stress fibers via physical interactions with beta-catenin. In conclusion, our results indicate that TGF-beta3-induced Smad signaling, in conjunction with beta-catenin, is involved in the reorganization of the actin cytoskeleton into a cortical pattern with a concomitant rounding of cells. J. Cell. Biochem. (c) 2009 Wiley-Liss, Inc.This article was published online on 28 May 2009. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 8 June 2009.
Authors:
Dongkyun Kim; Jungsoo Kim; Shin-Sung Kang; Eun-Jung Jin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  107     ISSN:  1097-4644     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  622-9     Citation Subset:  IM    
Copyright Information:
2009 Wiley-Liss, Inc.
Affiliation:
Department of Biological Sciences, Wonkwang University, Iksan, Chunbuk, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism*
Animals
Cell Shape
Chick Embryo
Chondrogenesis*
Cytoskeleton / metabolism
Limb Buds / cytology,  embryology*
Mesenchymal Stem Cells / cytology*,  physiology
Signal Transduction / physiology*
Smad2 Protein / metabolism*
Stress Fibers
Transforming Growth Factor beta3 / pharmacology*
beta Catenin / metabolism*
Chemical
Reg. No./Substance:
0/Actins; 0/Smad2 Protein; 0/Transforming Growth Factor beta3; 0/beta Catenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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