| Transforming growth factor beta regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts. | |
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MedLine Citation:
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PMID: 3422628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibronectin (FN) polymorphism is caused by alternative splicing patterns in at least three regions of the primary transcript of a single gene. Using a monoclonal antibody (Mab) specific for an FN segment (ED-A), that can be included or omitted from the molecule depending on the pattern of splicing, we have examined whether transforming growth factor beta (TGF-beta) and dexamethasone, which are both known to increase the level of total FN, regulate the levels of different FN isoforms. We found that, while dexamethasone does not significantly change the ratio between the total FN and the ED-A containing FN, TGF-beta preferentially increases the expression of the FN isoform containing the ED-A sequence. |
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Authors:
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E Balza; L Borsi; G Allemanni; L Zardi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 228 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-25 Completed Date: 1988-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 42-4 Citation Subset: IM |
Affiliation:
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Cell Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cells, Cultured Dexamethasone / pharmacology Fibroblasts / metabolism Fibronectins / metabolism* Gene Expression Regulation Humans Peptides / pharmacology* Sequence Homology, Nucleic Acid Transcription, Genetic Transforming Growth Factors |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 0/Peptides; 50-02-2/Dexamethasone; 76057-06-2/Transforming Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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