| Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types. | |
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MedLine Citation:
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PMID: 7689839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide is a mediator of paracrine cell signalling. An inducible form of nitric oxide synthase (iNOS) is expressed in macrophages and in Swiss 3T3 cells. Transforming growth factor beta (TGF-beta) is a cytokine that modulates many cellular functions. We find that TGF-beta cannot induce iNOS mRNA expression, either in macrophage cell lines or in Swiss 3T3 cells. However, TGF-beta attenuates lipopolysaccharide induction of iNOS mRNA in macrophages. In contrast, TGF-beta enhances iNOS induction by phorbol ester, serum or lipopolysaccharide in 3T3 cells. Thus TGF-beta can inhibit or augment iNOS mRNA induction in response to primary inducers, depending on the cell type in question. |
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Authors:
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R S Gilbert; H R Herschman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 195 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-09-28 Completed Date: 1993-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 380-4 Citation Subset: IM |
Affiliation:
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Department of Biological Chemistry, UCLA School of Medicine 90024. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3T3 Cells Amino Acid Oxidoreductases / biosynthesis*, genetics Animals Cell Line Dexamethasone / pharmacology Enzyme Induction / drug effects Gene Expression Regulation, Enzymologic / drug effects* Genes / drug effects Lipopolysaccharides / pharmacology Macrophages / enzymology* Mice Nitric Oxide Synthase RNA, Messenger / metabolism Transcription, Genetic / drug effects Transforming Growth Factor beta / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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GMO-8042/GM/NIGMS NIH HHS; M24797//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 0/RNA, Messenger; 0/Transforming Growth Factor beta; 50-02-2/Dexamethasone; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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