Document Detail

Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types.
MedLine Citation:
PMID:  7689839     Owner:  NLM     Status:  MEDLINE    
Nitric oxide is a mediator of paracrine cell signalling. An inducible form of nitric oxide synthase (iNOS) is expressed in macrophages and in Swiss 3T3 cells. Transforming growth factor beta (TGF-beta) is a cytokine that modulates many cellular functions. We find that TGF-beta cannot induce iNOS mRNA expression, either in macrophage cell lines or in Swiss 3T3 cells. However, TGF-beta attenuates lipopolysaccharide induction of iNOS mRNA in macrophages. In contrast, TGF-beta enhances iNOS induction by phorbol ester, serum or lipopolysaccharide in 3T3 cells. Thus TGF-beta can inhibit or augment iNOS mRNA induction in response to primary inducers, depending on the cell type in question.
R S Gilbert; H R Herschman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  195     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-28     Completed Date:  1993-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  380-4     Citation Subset:  IM    
Department of Biological Chemistry, UCLA School of Medicine 90024.
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MeSH Terms
3T3 Cells
Amino Acid Oxidoreductases / biosynthesis*,  genetics
Cell Line
Dexamethasone / pharmacology
Enzyme Induction / drug effects
Gene Expression Regulation, Enzymologic / drug effects*
Genes / drug effects
Lipopolysaccharides / pharmacology
Macrophages / enzymology*
Nitric Oxide Synthase
RNA, Messenger / metabolism
Transcription, Genetic / drug effects
Transforming Growth Factor beta / pharmacology*
Grant Support
Reg. No./Substance:
0/Lipopolysaccharides; 0/RNA, Messenger; 0/Transforming Growth Factor beta; 50-02-2/Dexamethasone; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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