Document Detail


Transforming growth factor-beta 1 in polymyositis and dermatomyositis correlates with fibrosis but not with mononuclear cell infiltrate.
MedLine Citation:
PMID:  9143260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The idiopathic inflammatory myopathies are diseases of unknown etiology characterized by T cell-mediated myocytotoxicity in polymyositis and complement-mediated angiopathy of muscle fibers in dermatomyositis. A variable degree of fibrosis is present in muscles in these conditions both perimysially and endomysially. We evaluated the expression of TGF-beta 1, a pleiotropic cytokine with fibrogenic and immunomodulating activity, by means of quantitative-polymerase chain reaction and immunocytochemistry in DM and PM muscle biopsies. TGF-beta 1 mRNA was significantly higher in DM compared with controls, whereas in PM the values were not significantly different when compared with controls and DM. TGF-beta 1 was localized in connective tissue but did not correspond with mononuclear cell infiltrates. These findings suggest a correlation between TGF-beta 1 and connective tissue proliferation in inflammatory myopathy, while its immunomodulatory role remains to be elucidated.
Authors:
P Confalonieri; P Bernasconi; F Cornelio; R Mantegazza
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  56     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  479-84     Citation Subset:  IM    
Affiliation:
Department of Neuromuscular Diseases, National Neurological Institute C., Besta, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Connective Tissue / metabolism,  pathology
Dermatomyositis / metabolism*,  pathology*
Fibrosis
Humans
Immunohistochemistry
Middle Aged
Monocytes / pathology
Muscles / metabolism,  pathology
Polymerase Chain Reaction
Polymyositis / metabolism*,  pathology*
RNA, Messenger / metabolism
Transforming Growth Factor beta / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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