Document Detail

Transforming growth factor-β and abdominal aortic aneurysms.
MedLine Citation:
PMID:  22959236     Owner:  NLM     Status:  Publisher    
Abdominal aortic aneurysms (AAAs) are common problems in aged people which can be associated with severe complications including aortic rupture and death. Transforming growth factor-β (TGFβ) has been implicated as causative in the development of thoracic aortic aneurysms (TAAs). In contrast, current evidence suggests TGFβ inhibits AAA development. Polymorphisms in the TGFβ signaling components are associated with AAA in some human population studies. In experimental animals TGFβ protects against AAA formation, progression and rupture. In animal models of AAA TGFβ decreases aortic inflammatory cell infiltration, extracellular matrix degradation, and vascular smooth muscle cell apoptosis, all factors implicated in AAA pathogenesis. The TGFβ signaling pathway may provide a therapeutic target for AAA although better clarity is needed regarding the distinct roles of TGFβ in TAA and AAA.
Yutang Wang; Smriti Krishna; Philip J Walker; Paul Norman; Jonathan Golledge
Related Documents :
7453226 - Surgical repair of coarctation of the aorta in infants less than six months of age: inc...
591556 - Ascending aorta to femoral arteries bypass without opening the abdominal cavity. choice...
24147626 - Right ventricular outflow tract obstruction after sinus of valsalva aneurysm repair.
23369946 - Introduction of embryonic stem cells into vein grafts reduces intimal hyperplasia in mice.
25006566 - Hepatic artery pseudoaneurysm after surgical treatment for pancreatic cancer: minimally...
2948736 - Effects of intracoronary infusion of arterial blood or fluosol-da 20% on regional myoca...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-6
Journal Detail:
Title:  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology     Volume:  -     ISSN:  1879-1336     ISO Abbreviation:  Cardiovasc. Pathol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9212060     Medline TA:  Cardiovasc Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Queensland 4811, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analyses of GATA4, NKX2.5, and TFAP2B genes in subjects from southern China with sporadic congenital...
Next Document:  Conversion from bipolar disorder not otherwise specified (BP-NOS) to bipolar I or II in youth with f...