| Transforming growth factor β (TGF-β) levels in otherwise healthy subjects with impaired glucose tolerance. | |
| | |
MedLine Citation:
|
PMID: 21104643 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Introduction: Serum transforming growth factor beta (TGF-β) level is increased in type-2 diabetes mellitus (T2DM) and certain diabetic complications are mediated by this cytokine. Impaired glucose tolerance (IGT) is a prediabetic condition, and confers a risk for the development of certain diabetes-specific complications. However, no data is available regarding the alteration of TGF-β in IGT subjects. Therefore, we aimed to investigate TGF-β levels in otherwise healthy subjects with IGT. Material and methods: Thirty IGT subjects and 30 subjects relatively matched for age, sex and body mass index with normal glucose tolerance were enrolled. Subjects with overt diabetes, cardiovascular, renal or inflammatory disease, or on any medication were excluded. Relevant laboratory examinations were performed by routine methods. Assessment of TGF-β was made by a commercially available enzyme-linked immunosorbent assay kit. IGT and control subjects were compared for their clinical and laboratory parameters. Results: Serum TGF-β levels were found to be similar in IGT and normal glucose tolerance subjects (p 〈 0.05). No statistically significant correlation was found between TGF-β and other laboratory parameters, either in IGT subjects or in the whole study population. Conclusions: Serum TGF-β is not elevated in otherwise healthy subjects with IGT. The results of our study imply that the presence of IGT alone is not sufficient to induce TGF-β elevation; and for the alteration of TGF-β, worsening of metabolic risk factors may be required. (Pol J Endocrinol 2010; 61 (6): 691-694). |
| | |
Authors:
|
Halil Genc; Nuri Karadurmus; Ucler Kisa; Serkan Tapan; Ilkin Naharci; Alper Sonmez; Teoman Dogru |
Related Documents
:
|
17448563 - Relevance of casual undetected hyperglycemia among high-risk individuals for developing... 1151433 - Glucose metabolism and insulin response in the plasma and csf in motor neurone disease. 8792113 - Vascular complications in long-term south indian niddm of over 25 years' duration. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Endokrynologia Polska Volume: 61 ISSN: 0423-104X ISO Abbreviation: Endokrynol Pol Publication Date: 2010 Nov-Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370674 Medline TA: Endokrynol Pol Country: Poland |
Other Details:
|
Languages: eng Pagination: 691-4 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of perindopril and enalapril on plasma resistin levels in normotensive patients with coro...
Next Document: Inhibin B and FSH as markers of Sertoli cell function in impaired spermatogenesis.