Document Detail

Transformed malignant lymphoma from Lennert's lesion is a CD4+ T cell lymphoma: an immunohistochemical study.
MedLine Citation:
PMID:  2787089     Owner:  NLM     Status:  MEDLINE    
We describe a case of Lennert's lesion terminating in T cell non-Hodgkin's lymphoma (NHL). A 53-year-old woman showed inguinal lymphadenopathy. This was histologically interpreted as toxoplasmic lymphadenitis. However, Lennert's lesion was diagnosed in subsequent biopsies. Because additional lymphadenopathy and constitutional symptoms were absent, anti-neoplastic therapy was not given. During the five and a half years after the initial biopsy, generalized lymphadenopathy and constitutional symptoms developed. Histological examination of the cervical lymph node disclosed NHL, diffuse, large cell type. Transformed lymphoma cells were confirmed to be of peripheral T cell origin with a helper/inducer phenotype. We speculate that some cases of Lennert's lesion have a potentiality of spontaneous transformation into high grade malignant lymphoma associated with disappearance of epithelioid histiocytes.
A Ohsaka; K Saito; S Mori; S Sakamoto; Y Miura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society     Volume:  52     ISSN:  0001-5806     ISO Abbreviation:  Nippon Ketsueki Gakkai Zasshi     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-08-10     Completed Date:  1989-08-10     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  2984803R     Medline TA:  Nihon Ketsueki Gakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
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MeSH Terms
Antigens, Differentiation, T-Lymphocyte / analysis
Cell Transformation, Neoplastic
Lymphoma, Non-Hodgkin / diagnosis*,  pathology
Middle Aged
Reg. No./Substance:
0/Antigens, Differentiation, T-Lymphocyte

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