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Transformation of type specificity of meningococci; change in heritable type induced by type-specific extracts containing desoxyribonucleic acid.
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MedLine Citation:
PMID:  13069637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Heritable type-specific traits have been induced in meningococcus populations by exposure to desoxyribonucleic acid (DNA)-containing extracts derived from meningococcus cells of the type desired. The DNA has been shown to be an essential component of the transforming extract. As in the H. influenzae system, the reaction between the susceptible cell and the DNA responsible for the heritable change requires less than 15 minutes. Only a minute proportion of the total cells exposed to the DNA extracts for a short time are susceptible to the change; but in the growth and reproduction of bacteria susceptible cells appear with fairly predictable frequency. Type I specific traits have been induced in populations of RIIa and SIIa cells. Type IIa specificity has been induced in RIIa cells.
Authors:
H E ALEXANDER; W REDMAN
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  97     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1953 Jun 
Date Detail:
Created Date:  1953-12-01     Completed Date:  2003-05-01     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  Not Available    
Other Details:
Languages:  eng     Pagination:  797-806     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Neisseria meningitidis*
Nucleic Acids*
Chemical
Reg. No./Substance:
0/Nucleic Acids
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1953, by The Rockefeller Institute for Medical Research New York
Received Day: 23 Month: 1 Year: 1953
Print publication date: Day: 1 Month: 6 Year: 1953
Volume: 97 Issue: 6
First Page: 797 Last Page: 806
ID: 2136310
PubMed Id: 13069637

TRANSFORMATION OF TYPE SPECIFICITY OF MENINGOCOCCI : CHANGE IN HERITABLE TYPE INDUCED BY TYPE-SPECIFIC EXTRACTS CONTAINING DESOXYRIBONUCLEIC ACID
Hattie E. Alexander
Winifred Redman
From the Babies Hospital and the Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York


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