| Transformation of mononuclear phagocytes in vivo and malignant histiocytosis caused by a novel murine spleen focus-forming virus. | |
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MedLine Citation:
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PMID: 3873013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study of retrovirus-induced leukaemias in mice is a powerful tool for the elucidation of the normal regulation of the haematopoietic system. The acute murine spleen focus-forming viruses (SFFV) can be classified according to the haematopoietic lineage on which they exert their effects in the adult mouse. Here we report a new SFFV isolate, the AF-1 virus, with the novel ability to transform cells of the mononuclear phagocyte lineage. The virus was isolated from sarcomas that were induced on passage of a cloned Friend helper virus (F-MuLV, 643/22F) in newborn BALB/c mice. We have cloned the transforming defective subunit of the AF-1 viral complex in NRK cells and isolated several subclones. Analysis of the proviral genome in two non-producer cell clones reveals that AF-1 virus contains Harvey v-ras-specific sequences (Fig. 1). Thus, AF-1 virus is closely related to Harvey murine sarcoma virus (Ha-MSV), and is, at present, the only tool by which permanent cell lines can be obtained from mononuclear phagocytes in the mouse. |
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Authors:
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T Franz; J Löhler; A Fusco; I Pragnell; P Nobis; R Padua; W Ostertag |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature Volume: 315 ISSN: 0028-0836 ISO Abbreviation: Nature Publication Date: 1985 May 9-15 |
Date Detail:
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Created Date: 1985-06-20 Completed Date: 1985-06-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 149-51 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Transformation, Viral* Hematopoietic Stem Cells / microbiology Histiocytosis, Langerhans-Cell / genetics, microbiology* Macrophages / microbiology Mice Monocytes / microbiology* Oncogenes* Phagocytes / microbiology* Retroviridae / genetics, pathogenicity* Spleen / microbiology |
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