Document Detail


Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine.
MedLine Citation:
PMID:  23038156     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Simple substitution of d-lysine with d-arginine in antimicrobial peptide (RLA) considerably improved its membrane permeability and increased mitochondrial accumulation. The potential use of RLA in preventing apoptotic cell death is also demonstrated through delivery of the Bcl-x(L) BH4 domain peptide.
Authors:
Ikuhiko Nakase; Shinya Okumura; Sayaka Katayama; Hisaaki Hirose; Sílvia Pujals; Hirofumi Yamaguchi; Satoko Arakawa; Shigeomi Shimizu; Shiroh Futaki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. nakase@scl.kyoto-u.ac.jp futaki@scl.kyoto-u.ac.jp.
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