| Transformation of the 5q- syndrome to acute lymphoblastic leukemia: a report of two cases and review of the literature. | |
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MedLine Citation:
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PMID: 21487529 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Myelodysplastic syndrome (MDS) with an isolated deletion of the long arm of chromosome 5 (5q- syndrome) is a distinct subtype of MDS with an indolent course that rarely transforms to acute leukemia. Deletion of the long arm of chromosome 5 has also been reported in rare cases of de novo B-lymphoblastic leukemia. We present two cases of 5q- syndrome with a similar and unusual course of transformation to lymphoblastic leukemia while on Lenalidomide. These two patients achieved an initial response; however, later acquired a second cytogenetic abnormality, became refractory to treatment and evolved into acute leukemia. At the time of transformation, both patients had recurrence of the 5q- abnormality. Review of the literature and the mechanisms of transformation of the 5q-syndrome into an acute leukemia are discussed. Although the relationship between the events in our cases remains unclear, the intriguing similarity between the two cases raises a question whether immune modulators can alter the natural course of MDS. To our knowledge, no similar cases were previously reported in the literature. |
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Authors:
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Nicole M Agostino; Basil Ahmed; Dan Popescu; Shereen Gheith |
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Publication Detail:
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Type: Journal Article Date: 2011-03-22 |
Journal Detail:
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Title: International journal of clinical and experimental pathology Volume: 4 ISSN: 1936-2625 ISO Abbreviation: Int J Clin Exp Pathol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101480565 Medline TA: Int J Clin Exp Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 322-6 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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