Document Detail

Transfollicular delivery of linoleic acid in human scalp skin: permeation study and microautoradiographic analysis.
MedLine Citation:
PMID:  18492146     Owner:  NLM     Status:  In-Data-Review    
There are a large number of studies on the pharmacological activity of lineolic acid (LA) on the skin; however, very little work has been carried out to determine how LA targets the follicular structure. The aim of this study was to identify the preferred route of penetration of LA and to localize the molecule, using a microautoradiographic technique associated with a compartmental approach. In an in vitro test using topical application of 0.05 g of a formulation containing 1% of LA, 10% of the total recovery was found in the stratum corneum and dermis after 6 h. Microautoradiographic analysis of a 'virtual' slide showed most of the silver grains, i.e. LA, at the hair sheath, and none in the dermal compartment, confirming the diffusion of LA through a preferred transfollicular route. These results show, for the first time on human scalp skin, that the combination of compartmental analysis and microautoradiography points to a preferred transfollicular route of diffusion of topically applied LA. Thanks to its high-resolution, microautoradiography offers the advantage of providing detailed in situ information on the delivery of LA in the skin, including the cellular location of the molecule.
V Raufast; A Mavon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cosmetic science     Volume:  28     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2008-05-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  117-23     Citation Subset:  -    
Laboratoire de Pharmacocinétique Cutanée, Institut de Recherche Pierre Fabre, Castanet-Tolosan cedex, France.
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