Document Detail


Transfers of frozen-thawed human embryos in cycles stimulated by HMG.
MedLine Citation:
PMID:  2108985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 130 transfers of frozen-thawed (F-T) human embryos was carried out after moderate ovarian stimulation with human menopausal gonadotrophin (HMG). Embryos were replaced 3 days after the spontaneous luteinizing hormone (LH) surge or 4 days if ovulation was induced by human chorionic gonadotrophin (HCG). Embryos were thawed a few hours prior to transfer. One-hundred-and-twenty-three transfers were effective and 23 pregnancies were achieved. The rate of ongoing pregnancies per transfer was 17.9% (22/123). The survival rate of embryos originating from cycles stimulated by a combination of an LHRH analogue and HMG in a long protocol (LA-HMG protocol) was significantly lower when compared with the rate of embryos retrieved from clomiphene citrate-HMG (CC-HMG protocol) stimulated cycles (52 versus 67%, P less than 0.05). When fresh embryos originated from cycles stimulated with an LHRH analogue and HMG in a short protocol (SA-HMG protocol), the survival rate was not affected (59 versus 67%, NS). Although the difference was not significant, the ongoing pregnancy rate per transfer according to the three protocols from which the embryos originated seemed to be better with the SA-HMG protocol: 16% with the CC-HMG protocol, 14.5% with the LA-HMG protocol versus 27.6% with the SA-HMG protocol. The success rate was independent of the number of F-T transferred embryos if at least one embryo with 100% intact blastomeres was replaced.
Authors:
J Lornage; D Boulieu; C Mathieu; J F Guerin; M C Pinatel; R James; C Alvarado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  5     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-05-16     Completed Date:  1990-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  60-5     Citation Subset:  IM    
Affiliation:
Laboratoire de Biologie de la Reproduction et du Développement and L'Hôpital Edouard Herriot Lyon, France.
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MeSH Terms
Descriptor/Qualifier:
Cryopreservation
Embryo Transfer / methods*
Female
Fertilization in Vitro / methods*
Freezing
Humans
Menotropins / therapeutic use
Ovulation Induction
Chemical
Reg. No./Substance:
61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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