Document Detail


Transferrin receptor in proliferation of T lymphocytes in infants with iron deficiency.
MedLine Citation:
PMID:  17617082     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to contribute to clarify the mechanism of cellular immune insufficiency occurring during iron deficiency. We studied the expression of the transferrin receptor (TfR) which is called as CD71, on the surface of T lymphocytes in infants with iron deficiency (with and without anemia). A total of 33 infants, aged between 7 and 26 months were included in this study. These subjects were divided into three groups: (i) latent iron deficiency (LID) (group 1), (ii) iron deficiency anemia (IDA) (group 2), and (iii) healthy infants (group 3). Both CD3 levels and CD71 expression of T lymphocytes were analysed by flow cytometry before and after phytohaemagglutinin (PHA) stimulation. The percentage of CD3(+) lymphocytes in infants with IDA was lower than that in controls after PHA stimulation (mean +/- SD, 48.6 +/-10.5% vs. 70.7 +/-7.8%, P < 0.001). The TfR expression of T lymphocytes (CD3 + CD71%) increased in all three groups after PHA stimulation (P < 0.001). No significant difference was seen among the three groups with respect to CD3 + CD71%. Although there was a reduction in the proliferative capacity of T lymphocytes in infants with IDA, their ability to express transferrin receptor on T-lymphocyte cell surface was normal.
Authors:
H Artac; M Coskun; I Karadogan; O Yegin; A Yesilipek
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of laboratory hematology     Volume:  29     ISSN:  1751-5521     ISO Abbreviation:  -     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300213     Medline TA:  Int J Lab Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  IM    
Affiliation:
Division of Immunology and Allergy, Department of Pediatrics, Meram Medical Faculty, Selcuk University, Konya, Turkey. hasibeartac@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / blood*,  immunology
Antigens, CD / blood
Antigens, CD3 / blood
Child, Preschool
Flow Cytometry
Humans
Infant
Phytohemagglutinins / pharmacology
Receptors, Transferrin / analysis*,  blood
T-Lymphocytes / drug effects,  immunology*
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD3; 0/CD71 antigen; 0/Phytohemagglutinins; 0/Receptors, Transferrin

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