Document Detail

Transfer of methadone across the dually perfused preterm human placental lobule.
MedLine Citation:
PMID:  18166326     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to determine the effect of gestational age and P-glycoprotein expression on transplacental transfer of methadone. STUDY DESIGN: Dual perfusion of placental lobule was utilized. Methadone (200 ng/mL) and its [3H]-isotope were cotransfused from the maternal-to-fetal circuit with the marker compound antipyrine (20 microg/mL) and its [14C]-isotope. Concentration of the drugs in trophoblast tissue and both circuits was determined by liquid scintillation spectrometry. RESULTS: Fetal transfer rate of methadone in preterm placentas was 19 +/- 5.8%, and in term placentas it was 31 +/- 9.7% (P < .01). Clearance index of methadone in preterm placentas (0.57 +/- 0.2) was lower than in term placentas (0.95 +/- 0.3, P < .01). P-glycoprotein expression was higher in preterm than term placentas. CONCLUSION: The ex vivo transfer of methadone across preterm placentas is 30% lower than in term placentas.
Tatiana N Nanovskaya; Ilona A Nekhayeva; Gary D V Hankins; Mahmoud S Ahmed
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  198     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126.e1-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555-0587, USA.
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MeSH Terms
Gestational Age
Maternal-Fetal Exchange / drug effects*
Methadone / pharmacology*
Organ Culture Techniques
Perfusion / methods
Placenta / drug effects*,  metabolism
Placental Circulation / drug effects*
Premature Birth*
Reference Values
Risk Factors
Sensitivity and Specificity
Term Birth
Grant Support
Reg. No./Substance:

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