Document Detail

Transfer of gas from the acinus during continuous flow and intermittent positive pressure ventilation.
MedLine Citation:
PMID:  8191037     Owner:  NLM     Status:  MEDLINE    
We used a technique of measuring Xenon133 washout (XeW) from the alveolar space to evaluate transfer of gas from the acinus (Mackenzie et al., J. Appl. Physiol. 68: 2013-2018, 1990) during 2 min of apnea, 2 min of tracheal insufflation with oxygen (TRIO) and 90 sec of intermittent positive pressure ventilation (IPPV) in 6 anesthetized and paralyzed dogs. Xenon133 dissolved in saline was injected into an occluded acinar region through a pulmonary artery catheter, and XeW was measured by gamma scintillation scanning. With this technique, XeW during apnea represents the contribution of cardiogenic oscillations in regional flow. The XeW rate constant (min-1 +/- SE) was 0.37 +/- 0.03 during apnea. This was not different (P > 0.05) with TRIO (0.29 +/- 0.04). With IPPV, the rate constant increased to 3.49 +/- 0.39, faster than with either apnea or TRIO (P < 0.001). We conclude that: (1) TRIO does not increase convective gas transfer from the acini compared to apnea; and (2) transfer of gas out of the acini due to cardiogenic oscillations is a very small portion of the total gas eliminated during IPPV.
F C Forrest; P B Randalls; G M Barnas; B H Hoff; J Oletsky; C F Mackenzie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  95     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-20     Completed Date:  1994-06-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM; S    
Department of Anesthesiology, University of Maryland, Baltimore 21201.
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MeSH Terms
Apnea / physiopathology
Biological Transport / physiology
Gamma Cameras
Intermittent Positive-Pressure Ventilation*
Oxygen / pharmacokinetics
Pulmonary Alveoli / physiology*
Pulmonary Gas Exchange / physiology
Xenon / pharmacokinetics*
Xenon Radioisotopes
Reg. No./Substance:
0/Xenon Radioisotopes; 7440-63-3/Xenon; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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