Document Detail

Transfer of extracellular vesicles during immune cell-cell interactions.
MedLine Citation:
PMID:  23278745     Owner:  NLM     Status:  MEDLINE    
The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen-presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell-cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell-cell interactions.
Cristina Gutiérrez-Vázquez; Carolina Villarroya-Beltri; María Mittelbrunn; Francisco Sánchez-Madrid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  251     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-28     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  125-42     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
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MeSH Terms
Antigen-Presenting Cells / immunology*
Cell Communication / immunology
Immunity, Cellular*
Immunological Synapses / immunology*
Proteins / metabolism
RNA, Small Interfering / metabolism
Secretory Vesicles / immunology*
T-Lymphocytes / immunology*
Grant Support
294340//European Research Council
Reg. No./Substance:
0/Proteins; 0/RNA, Small Interfering

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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