| Transfer of bisphenol A across the human placenta. | |
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MedLine Citation:
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PMID: 20350650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of the investigation was to study placental transfer and conjugation of bisphenol A (BPA) across the human placenta. STUDY DESIGN: Human placentae obtained from healthy term singleton pregnancies were utilized in a dual recirculating model of ex vivo placental perfusion. Seven placentae were perfused with BPA (10 ng/mL) added to the maternal perfusate for 180 minutes. Antipyrine and fluorescein isothiocyanate dextran were used as positive and negative controls, respectively, to validate integrity of the circuits. Concentrations of BPA and its conjugates were determined by liquid chromatography-mass spectrometry. RESULTS: The transfer percentage for antipyrine and BPA were 25.5 +/- 1.13% and 27.0 +/- 1.88%, respectively, and the transfer index for BPA was 1.1 +/- 0.09 after 180 minutes of perfusion. Only 3.2 +/- 1.6% of BPA in the fetal compartment was in the conjugated form. CONCLUSION: Bisphenol A at low environmentally relevant levels can transfer across the human placenta, mainly in active unconjugated form. |
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Authors:
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Biju Balakrishnan; Kimiora Henare; Eric B Thorstensen; Anna P Ponnampalam; Murray D Mitchell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 393.e1-7 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Liggins Institute, University of Auckland, Auckland, New Zealand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants, Occupational
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pharmacokinetics* Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics Antipyrine / pharmacokinetics Chromatography, High Pressure Liquid Dextrans / pharmacokinetics Female Fluorescein-5-isothiocyanate / analogs & derivatives, pharmacokinetics Fluorescent Dyes / pharmacokinetics Glucuronides / pharmacokinetics* Humans Mass Spectrometry Maternal-Fetal Exchange Phenols / pharmacokinetics* Placenta / blood supply, metabolism* Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Occupational; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Fluorescent Dyes; 0/Glucuronides; 0/Phenols; 0/bisphenol A glucuronide; 0/fluorescein isothiocyanate dextran; 3326-32-7/Fluorescein-5-isothiocyanate; 60-80-0/Antipyrine; 80-05-7/bisphenol A; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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