| Transfer of bilirubin uridine diphosphate-glucuronyltransferase to enzyme-deficient rats. | |
| | |
MedLine Citation:
|
PMID: 4319199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cells from a clonal strain (MH(1)C(1)) of rat hepatoma were transplanted subcutaneously into two homozygous Gunn rats, which are jaundiced because the enzyme bilirubin uridine diphosphate-glucuronyltransferase is absent from the liver. Because of the enzyme activity present in the transplanted cells, the recipient rats developed the capacity to conjugate bilirubin and reverted in large part to a normal pattern of bilirubin excretion. |
| | |
Authors:
|
H E Rugstad; S H Robinson; C Yannoni; A H Tashjian |
Related Documents
:
|
171059 - Interaction of normal and tumor transfer rna methyltransferases with ethionine-induced ... 173229 - Carcinofetal alterations in glycogen phosphorylase isozymes in rat hepatomas. 15804599 - Recombinant rat il-1beta and il-6 synergistically enhance c3 mrna levels and complement... 9208369 - Inhibition of l-fucokinase from rat liver by l-fucose analogues in vitro. 50249 - Alpha-fetoprotein detected in rat transplantable hepatomas by radioimmunoassay. 3033849 - Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vit... 6467529 - Altered cerebral vessel innervation in the spontaneously hypertensive rat. 2462659 - The mechanisms of proteinuria in aging rats. 3549859 - Lactation-induced changes in calcium handling by rat pancreatic islets. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 170 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1970 Oct |
Date Detail:
|
Created Date: 1970-11-25 Completed Date: 1970-11-25 Revised Date: 2011-12-08 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 553-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bilirubin / blood, metabolism Biotransformation Carbon Isotopes Carcinoma, Hepatocellular / enzymology* Hyperbilirubinemia, Hereditary / metabolism Liver / enzymology*, metabolism Liver Neoplasms Male Metabolism, Inborn Errors* Neoplasm Transplantation Rats Transferases / metabolism* Uracil Nucleotides |
| Chemical | |
Reg. No./Substance:
|
0/Carbon Isotopes; 0/Uracil Nucleotides; 635-65-4/Bilirubin; EC 2.-/Transferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spontaneous in vitro neoplastic transformation of adult human prostatic epithelium.
Next Document: Rhinoviraemia.