Document Detail


Transfer RNA modifications: nature's combinatorial chemistry playground.
MedLine Citation:
PMID:  23139145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following synthesis, tRNAs are peppered by numerous chemical modifications which may differentially affect a tRNA's structure and function. Although modifications affecting the business ends of a tRNA are predictably important for cell viability, a majority of modifications play more subtle structural roles that can affect tRNA stability and folding. The current trend is that modifications act in concert and it is in the context of the specific sequence of a given tRNA that they impart their differing effects. Recent developments in the modification field have highlighted the diversity of modifications in tRNA. From these, the combinatorial nature of modifications in explaining previously described phenotypes derived from their absence has emerged as a growing theme.
Authors:
Jane E Jackman; Juan D Alfonzo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-11-08
Journal Detail:
Title:  Wiley interdisciplinary reviews. RNA     Volume:  4     ISSN:  1757-7012     ISO Abbreviation:  Wiley Interdiscip Rev RNA     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2012-12-20     Completed Date:  2013-06-20     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101536955     Medline TA:  Wiley Interdiscip Rev RNA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-48     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Humans
Protein Biosynthesis / genetics,  physiology
RNA Processing, Post-Transcriptional*
RNA, Transfer* / chemistry,  genetics,  metabolism
Structure-Activity Relationship
Grant Support
ID/Acronym/Agency:
R01 GM084065/GM/NIGMS NIH HHS; R01 GM084065/GM/NIGMS NIH HHS; R01 GM087543/GM/NIGMS NIH HHS; R01-GM087543/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
9014-25-9/RNA, Transfer
Comments/Corrections

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