Document Detail


Transfer of N2O, CO and HTO in the artificially perfused guinea-pig placenta.
MedLine Citation:
PMID:  882728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fetal vascular system of the guinea-pig placenta at term was perfused with a dextran solution at a rate of 3.6 and 9 ml/min, while the uteroplacental (maternal) blood flow was adjusted to 4-18 ml/min. N2O, CO, and tritiated water (HTO) were added to the perfusion fluid. The effectiveness of placental transfer of these substances, i.e. the actual transfer related to the maximum transfer occuring when the fetal vein equlibrates with the maternal artery, was calculated. It was found that the effectiveness of the CO transfer was 98% (SD = 2%). The effectiveness of the N2O transfer was about 90% (SD = 6%) when the maternofetal flow ratio was two and about 75% (SD = 13%) when the ratio was one. The effectiveness of the transfer was the same for HTO and N2O. It was concluded: (1) The vascular and diffusional shunts on the fetal side of the placenta are only 2%. (2) The placenta has the properties of a countercurrent system in which the effectiveness of gas transfer is decreased by about 25% at a flow ratio of one and by 10% at a flow ratio of two by inhomogeneity of the maternofetal flow ratio. (3) The diffusional resistance for HTO is unmeasurabbly small; its transfer is solely limited by blood flow.
Authors:
W Moll; E Kastendieck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  29     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-09-17     Completed Date:  1977-09-17     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  283-302     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Monoxide / metabolism*
Countercurrent Distribution
Dextrans
Female
Guinea Pigs / physiology*
Maternal-Fetal Exchange*
Microspheres
Nitrous Oxide / metabolism*
Perfusion
Placenta / metabolism*
Pregnancy
Regional Blood Flow
Water / metabolism*
Chemical
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 630-08-0/Carbon Monoxide; 7732-18-5/Water; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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