| Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk. | |
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MedLine Citation:
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PMID: 19759353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metyrapone, an inhibitor of corticosteroid biosynthesis, is used in the diagnosis and treatment of adrenocortical hyperfunction. The authors describe the excretion of metyrapone and its metabolite, rac-metyrapol, in milk from a lactating woman requiring metyrapone treatment (250 mg 4 times daily). At steady state, the average concentrations in milk and absolute and relative infant doses were 11 microg/L, 1.7 microg/kg/d, and 0.02%, respectively, for metyrapone, and 48.5 microg/L, 7.3 microg/kg/d, and 0.08%, respectively, for rac-metyrapol. The findings suggest that maternal metyrapone use during breastfeeding is extremely unlikely to be a significant risk for the breastfed infant. |
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Authors:
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Neil J Hotham; Kenneth F Ilett; L Peter Hackett; Mark R Morton; Peter Muller; William M Hague |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-16 |
Journal Detail:
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Title: Journal of human lactation : official journal of International Lactation Consultant Association Volume: 25 ISSN: 1552-5732 ISO Abbreviation: J Hum Lact Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-03 Completed Date: 2010-02-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709498 Medline TA: J Hum Lact Country: United States |
Other Details:
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Languages: eng Pagination: 451-4 Citation Subset: N |
Affiliation:
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Department of Pharmacy, Women's and Children's Hospital, North Adelaide, South Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Area Under Curve Breast Feeding Chromatography, High Pressure Liquid Cushing Syndrome / drug therapy Enzyme Inhibitors / analysis, pharmacokinetics*, therapeutic use Female Humans Infant Infant, Newborn Metyrapone / analysis, pharmacokinetics*, therapeutic use Milk, Human / chemistry*, metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 54-36-4/Metyrapone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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