Document Detail


Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk.
MedLine Citation:
PMID:  19759353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metyrapone, an inhibitor of corticosteroid biosynthesis, is used in the diagnosis and treatment of adrenocortical hyperfunction. The authors describe the excretion of metyrapone and its metabolite, rac-metyrapol, in milk from a lactating woman requiring metyrapone treatment (250 mg 4 times daily). At steady state, the average concentrations in milk and absolute and relative infant doses were 11 microg/L, 1.7 microg/kg/d, and 0.02%, respectively, for metyrapone, and 48.5 microg/L, 7.3 microg/kg/d, and 0.08%, respectively, for rac-metyrapol. The findings suggest that maternal metyrapone use during breastfeeding is extremely unlikely to be a significant risk for the breastfed infant.
Authors:
Neil J Hotham; Kenneth F Ilett; L Peter Hackett; Mark R Morton; Peter Muller; William M Hague
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-09-16
Journal Detail:
Title:  Journal of human lactation : official journal of International Lactation Consultant Association     Volume:  25     ISSN:  1552-5732     ISO Abbreviation:  J Hum Lact     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-12-03     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709498     Medline TA:  J Hum Lact     Country:  United States    
Other Details:
Languages:  eng     Pagination:  451-4     Citation Subset:  N    
Affiliation:
Department of Pharmacy, Women's and Children's Hospital, North Adelaide, South Australia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Area Under Curve
Breast Feeding
Chromatography, High Pressure Liquid
Cushing Syndrome / drug therapy
Enzyme Inhibitors / analysis,  pharmacokinetics*,  therapeutic use
Female
Humans
Infant
Infant, Newborn
Metyrapone / analysis,  pharmacokinetics*,  therapeutic use
Milk, Human / chemistry*,  metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 54-36-4/Metyrapone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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