| Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues. | |
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MedLine Citation:
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PMID: 6623523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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[3H]Retronecine and [3H]necic acid-labelled senecionine and seneciphylline were prepared biosynthetically with seedlings of Senecio vulgaris L. using [2,3-3H]putrescine and [4,5-3H]isoleucine, respectively, as precursors. Lactating rats dosed with these differently labelled pyrrolizidine alkaloids (PAs) excreted within 3 h approx. 0.08% of the applied radioactivity in the milk mainly as yet not identified water-soluble retronecine-derived metabolites and with approx. 0.02% as unchanged PAs. Highest tissue levels of PAs and metabolites, 6 h after administration, were found in liver and lungs. |
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Authors:
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J Lüthy; T Heim; C Schlatter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology letters Volume: 17 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 283-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dicarboxylic Acids / metabolism Female Kinetics Milk / metabolism* Plants, Toxic* Pregnancy Pyrrolizidine Alkaloids / metabolism* Rats Senecio* Tissue Distribution Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Dicarboxylic Acids; 0/Pyrrolizidine Alkaloids; 10028-17-8/Tritium; 130-01-8/senecionine; 13588-16-4/necic acid; 480-81-9/seneciphylline; 480-85-3/retronecine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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