Document Detail


Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues.
MedLine Citation:
PMID:  6623523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[3H]Retronecine and [3H]necic acid-labelled senecionine and seneciphylline were prepared biosynthetically with seedlings of Senecio vulgaris L. using [2,3-3H]putrescine and [4,5-3H]isoleucine, respectively, as precursors. Lactating rats dosed with these differently labelled pyrrolizidine alkaloids (PAs) excreted within 3 h approx. 0.08% of the applied radioactivity in the milk mainly as yet not identified water-soluble retronecine-derived metabolites and with approx. 0.02% as unchanged PAs. Highest tissue levels of PAs and metabolites, 6 h after administration, were found in liver and lungs.
Authors:
J Lüthy; T Heim; C Schlatter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  17     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  283-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dicarboxylic Acids / metabolism
Female
Kinetics
Milk / metabolism*
Plants, Toxic*
Pregnancy
Pyrrolizidine Alkaloids / metabolism*
Rats
Senecio*
Tissue Distribution
Tritium / diagnostic use
Chemical
Reg. No./Substance:
0/Dicarboxylic Acids; 0/Pyrrolizidine Alkaloids; 10028-17-8/Tritium; 130-01-8/senecionine; 13588-16-4/necic acid; 480-81-9/seneciphylline; 480-85-3/retronecine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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