Document Detail

Transfer of 125I-albumin from blood to brain in newborn rats and the effect of hyperbilirubinemia on the transfer.
MedLine Citation:
PMID:  1391275     Owner:  NLM     Status:  MEDLINE    
Transfer of albumin from blood into cerebellum and cerebrum was examined in postnatal rats. 125I-Albumin was injected into rats on day 3, 7, 14, 28 or 70. The ratio of albumin concentration in the cerebellum or in the cerebrum to that in the plasma 2 h after the injection, hereinafter termed the relative albumin level (RA), was calculated and used as a criterion for the albumin transfer. The RA in both the cerebellum and the cerebrum decreased with age, but plateaued between days 28 and 70. The level was significantly higher in the cerebellum than in the cerebrum on days 3 and 7. This was not observed, however, on days 28 and 70. Significant correlations were indicated between 125I-albumin levels in the plasma and those in the cerebellum or cerebrum on days 7 and 14, but not on day 28. No significant difference in the RA in the cerebellum and the cerebrum was detected between jaundiced homozygous Gunn rats and control nonjaundiced rats at all ages examined. These results demonstrated that albumin could enter the brain tissue from the blood at least until postnatal day 14 and that the endogenous bilirubin had no effect on the albumin transfer into the brain. The relationship between the immaturity of brain and the transfer of albumin into the brain was discussed.
M Ohsugi; H Sato; H Yamamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  62     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Department of Anatomy, Mie University School of Medicine, Tsu, Japan.
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MeSH Terms
Age Factors
Animals, Newborn
Biological Transport, Active
Blood-Brain Barrier / physiology*
Brain / metabolism
Cerebellum / metabolism
Hyperbilirubinemia / metabolism*
Rats, Gunn
Serum Albumin / metabolism*
Reg. No./Substance:
0/Serum Albumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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