Document Detail


Transesophageal defibrillation: animal studies and preliminary clinical observations.
MedLine Citation:
PMID:  7686658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ventricular fibrillation (VF) that fails to respond to transthoracic defibrillation leaves the clinician with few alternatives. The purpose of this study was to develop a technique of rescue defibrillation by use of transesophageal electrodes. Fourteen anesthetized dogs (20-30 kg) were investigated in this study. Two electrodes (300 mm2) were mounted 8 cm apart on an esophageal probe and inserted approximately 40 cm from the mouth. VF was induced using AC current delivered to the myocardium. Defibrillation was then performed between the distal electrode (anode) and anterior skin patch (cathode). After 15 seconds of induced VF, transesophageal and transthoracic defibrillation thresholds (DFTs) were determined in random order. The esophageal DFT (90 +/- 15 joules) tended to be lower than the transthoracic DFT (115 +/- 35 joules), though this difference was not statistically significant. One dog could not be defibrillated by transthoracic defibrillation but responded to transesophageal defibrillation. Esophageal electrodes were also useful for arrhythmia discrimination and ventricular pacing (pacing threshold of 38 +/- 5 mA at a pulse duration of 2.5 msec). Following transesophageal DFT determination, in ten dogs (total energy of 600 +/- 150 joules), acute esophageal histopathology demonstrated mild to severe focal injury to the mucosa and/or muscular layers. However, esophagi in four chronic dogs (total energy of 470 +/- 110 joules) showed no gross evidence of mucosal damage, perforation, or stricture 4 weeks following defibrillation. Histopathology showed only focal myocyte atrophy and repair. As a last resort, transesophageal defibrillation was performed in the emergency room on four patients with out-of-hospital refractory VF who failed > 6 high energy transthoracic shocks.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
T J Cohen; M C Chin; D G Oliver; M M Scheinman; J C Griffin
Related Documents :
3795968 - Experimental and clinical pharmacology of bretylium tosylate in acute myocardial infarc...
25336888 - Carbamazepine induced atrial tachycardia with complete av block.
22556978 - Heart - its structure metabolism and cardiac tonics - as described in ayurveda.
22815328 - Cardiac outcomes in adults with supravalvar aortic stenosis.
16932628 - Coronary artery disease in patients with systemic lupus erythematosus.
21793948 - Impaired cardiac function in chronic fatigue syndrome measured using magnetic resonance...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  16     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1285-92     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of California, San Francisco.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Cardiac Pacing, Artificial / methods
Dogs
Electric Countershock / methods*
Electrodes
Esophagus / injuries
Female
Heart Arrest / therapy
Humans
Male
Middle Aged
Ventricular Fibrillation / therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects on cardiac performance of atrioventricular node catheter ablation using radiofrequency curre...
Next Document:  Detection of atrial activation by intraventricular electrogram morphology analysis: a study to deter...