Document Detail


Transepithelial electric potential difference in newborns undergoing phototherapy.
MedLine Citation:
PMID:  3562127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When hyperbilirubinemic newborn babies underwent phototherapy, a significant decrease of the transepithelial electric potential difference of duodenal mucosa was observed, while the content of nonconjugated bilirubin and photobilirubins in the duodenal juice increased. This may indicate that the mucosa barrier function is damaged by bilirubin, with resulting increased sodium and water secretion into the gut. This phenomenon seems to be one of the reasons for diarrhea which is frequently observed in newborns undergoing phototherapy. Further investigations are necessary to understand the mechanism of bilirubin toxicity of the gut in detail.
Authors:
K Jaehrig; E H Ballke; A Koenig; P Meisel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  21     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-05-18     Completed Date:  1987-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bile / metabolism
Bilirubin / metabolism
Duodenum / metabolism,  physiopathology*
Electrophysiology
Gastric Mucosa / physiopathology
Humans
Hyperbilirubinemia / physiopathology,  therapy*
Infant, Newborn
Intestinal Mucosa / metabolism,  physiopathology*
Osmolar Concentration
Phototherapy*
Chemical
Reg. No./Substance:
635-65-4/Bilirubin; 79619-29-7/photobilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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