Document Detail


Transepithelial antigen delivery in the small intestine: different paths, different outcomes.
MedLine Citation:
PMID:  23380572     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The intestinal epithelium is a dynamic barrier protecting the body from the multitudes of luminal micro-organisms present in the gut. However, this barrier is not impermeable and mechanisms exist that allow small amounts of antigen to traverse the epithelium in controlled manner to maintain tolerance and to mount immune responses. This review will summarize our current understanding of how luminal antigens traverse the small intestine epithelium without disrupting the epithelial barrier and how these antigen delivery pathways might influence the resulting immune responses.
RECENT FINDINGS: Recent findings have revealed four pathways for transepithelial antigen delivery in the absence of barrier disruption. We propose that during homeostasis, antigen introduced through microfold cells induces immunoglobulin A responses, antigen delivered by goblet cell-associated antigen passages contributes to peripheral tolerance, and antigen delivered by paracellular leak initiates immune responses in the mesenteric lymph node. In contrast, dendritic cell transepithelial dendrites may play an important role in host protection during pathogen infection, but do not appear to play a role in antigen capture by lamina propria dendritic cells in the steady state.
SUMMARY: These observations indicate that the route by which antigen crosses the epithelium directs the outcome of the subsequent immune response.
Authors:
Kathryn A Knoop; Mark J Miller; Rodney D Newberry
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in gastroenterology     Volume:  29     ISSN:  1531-7056     ISO Abbreviation:  Curr. Opin. Gastroenterol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-05     Completed Date:  2013-07-22     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  8506887     Medline TA:  Curr Opin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigen Presentation / immunology
Antigens / administration & dosage*
Dendritic Cells / immunology
Goblet Cells / immunology
Humans
Immune Tolerance / immunology
Immunity, Mucosal
Immunoglobulin A / biosynthesis
Intestinal Mucosa / immunology
Intestine, Small / immunology*
Grant Support
ID/Acronym/Agency:
AI077600/AI/NIAID NIH HHS; AI095550/AI/NIAID NIH HHS; DK064798/DK/NIDDK NIH HHS; DK097317/DK/NIDDK NIH HHS; R01 DK064798/DK/NIDDK NIH HHS; R01 DK097317/DK/NIDDK NIH HHS; U01 AI095550/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Immunoglobulin A
Comments/Corrections

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