Document Detail

Transepidermal water loss in young and aged healthy humans: a systematic review and meta-analysis.
MedLine Citation:
PMID:  23341028     Owner:  NLM     Status:  Publisher    
Transepidermal water loss (TEWL) is regarded as one of the most important parameters for characterizing skin barrier function but an agreed upon definition of what a "normal" TEWL is does not exist. In order to determine generalizable TEWL values for healthy adults, a systematic review and meta-analysis was conducted. The databases MEDLINE and EMBASE and publication lists were screened. After full-text appraisal of 398 studies, 231 studies were excluded due to unclear or insufficient reporting. 167 studies providing data about 50 skin areas were included in the final data synthesis. Pooled sample sizes ranged from n = 5 for the left cheek and the left lower back to a maximum of n = 2,838 for the right midvolar forearm area. The lowest TEWL of 2.3 (95 % CI 1.9-2.7) g/m(2)/h was calculated for the breast skin, the highest TEWL of 44.0 (39.8-48.2) g/m(2)/h for the axilla. TEWL in individuals being 65 years and above was consistently lower compared to the group of 18- to 64-year-old individuals. The quality of reporting TEWL in humans should be increased in future studies.
Jan Kottner; Andrea Lichterfeld; Ulrike Blume-Peytavi
Related Documents :
11697108 - In vitro and in vivo evaluation of poly(methylidene malonate 2.1.2) microparticles beha...
23584418 - The influence of thermal degradation on the electrodeposition of aluminium from an air-...
11219098 - Polymerization of udma using zinc particles and 4-meta with and without bpo.
19908468 - Facile preparation of superparamagnetic fe3o4/poly(st-co-mps)/sio2 composite particles ...
7054798 - The effect of the proline analogue l-azetidine-2-carboxylic acid (laca) on epidermal an...
1472908 - Microanalytical characterization and surface modification of tini orthodontic archwires.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Archives of dermatological research     Volume:  -     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Obstructive pulmonary disease in old age among individuals born preterm.
Next Document:  The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression i...