| Transdural motor cortex stimulation reverses neuropathic pain in rats: A profile of neuronal activation. | |
| | |
MedLine Citation:
|
PMID: 20817578 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Motor cortex stimulation (MCS) has been used to treat patients with neuropathic pain resistant to other therapeutic approaches; however, the mechanisms of pain control by MCS are still not clearly understood. We have demonstrated that MCS increases the nociceptive threshold of naive conscious rats, with opioid participation. In the present study, the effect of transdural MCS on neuropathic pain in rats subjected to chronic constriction injury of the sciatic nerve was investigated. In addition, the pattern of neuronal activation, evaluated by Fos and Zif268 immunolabel, was performed in the spinal cord and brain sites associated with the modulation of persistent pain. MCS reversed the mechanical hyperalgesia and allodynia induced by peripheral neuropathy. After stimulation, Fos immunoreactivity (Fos-IR) decreased in the dorsal horn of the spinal cord and in the ventral posterior lateral and medial nuclei of the thalamus, when compared to animals with neuropathic pain. Furthermore, the MCS increased the Fos-IR in the periaqueductal gray, the anterior cingulate cortex and the central and basolateral amygdaloid nuclei. Zif268 results were similar to those obtained for Fos, although no changes were observed for Zif268 in the anterior cingulate cortex and the central amygdaloid nucleus after MCS. The present findings suggest that MCS reverts neuropathic pain phenomena in rats, mimicking the effect observed in humans, through activation of the limbic and descending pain inhibitory systems. Further investigation of the mechanisms involved in this effect may contribute to the improvement of the clinical treatment of persistent pain. |
| | |
Authors:
|
Rosana L Pagano; Danielle V Assis; Joseph A Clara; Adilson S Alves; Camila S Dale; Manoel J Teixeira; Erich T Fonoff; Luiz R Britto |
Related Documents
:
|
20119458 - Radiation exposure in percutaneous spinal cord stimulation mapping: a preliminary report. 7784098 - The consumption of fentanyl is increased in rats with nociceptive but not with neuropat... 20732348 - Antinociceptive effect of ambroxol in rats with neuropathic spinal cord injury pain. 15378668 - Serotonin and noradrenaline reuptake inhibitors in animal models of pain. 19284508 - Toothache pain: behavioral impact and self-care strategies. 20178548 - Successful treatment of severe retro-peritoneal bleeding with recombinant factor viia i... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of pain (London, England) Volume: 15 ISSN: 1532-2149 ISO Abbreviation: Eur J Pain Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9801774 Medline TA: Eur J Pain Country: England |
Other Details:
|
Languages: eng Pagination: 268.e1-268.e14 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Laboratory of Neuromodulation and Experimental Pain, Hospital Sírio Libanês, São Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Seizures and intellectual outcome: Clinico-radiological study of 30 Egyptian cases of tuberous scler...
Next Document: Interobserver agreement in describing video capsule endoscopy findings: A multicentre prospective st...